SYME_ECOUT
ID SYME_ECOUT Reviewed; 113 AA.
AC Q1R2G2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Endoribonuclease SymE {ECO:0000255|HAMAP-Rule:MF_01193};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01193};
GN Name=symE {ECO:0000255|HAMAP-Rule:MF_01193}; OrderedLocusNames=UTI89_C5049;
OS Escherichia coli (strain UTI89 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=364106;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTI89 / UPEC;
RX PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA Gordon J.I.;
RT "Identification of genes subject to positive selection in uropathogenic
RT strains of Escherichia coli: a comparative genomics approach.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC -!- FUNCTION: Involved in the degradation and recycling of damaged RNA. It
CC is itself a target for degradation by the ATP-dependent protease Lon.
CC {ECO:0000255|HAMAP-Rule:MF_01193}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01193}.
CC -!- SIMILARITY: Belongs to the SymE family. {ECO:0000255|HAMAP-
CC Rule:MF_01193}.
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DR EMBL; CP000243; ABE10452.1; -; Genomic_DNA.
DR RefSeq; WP_000132612.1; NC_007946.1.
DR AlphaFoldDB; Q1R2G2; -.
DR EnsemblBacteria; ABE10452; ABE10452; UTI89_C5049.
DR KEGG; eci:UTI89_C5049; -.
DR HOGENOM; CLU_151239_0_0_6; -.
DR OMA; MRQHTRT; -.
DR Proteomes; UP000001952; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR HAMAP; MF_01193; Endoribonucl_SymE; 1.
DR InterPro; IPR007159; SpoVT-AbrB_dom.
DR InterPro; IPR014944; Toxin_SymE-like.
DR InterPro; IPR020883; TypeI_TA_SymE.
DR Pfam; PF08845; SymE_toxin; 1.
DR PROSITE; PS51740; SPOVT_ABRB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease; RNA-binding.
FT CHAIN 1..113
FT /note="Endoribonuclease SymE"
FT /id="PRO_0000297822"
FT DOMAIN 29..74
FT /note="SpoVT-AbrB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ SEQUENCE 113 AA; 12338 MW; 082A890F14375602 CRC64;
MTDTHSIAQP FEAEVSPANN RQLTVSYASR YPDYSRIPAI TLKGQWLEAA GFATGTAIDV
KVMEGCIVLT AQPPAAEESE LMQSLRQVCK LSARKQRQVQ EFIGVIAGKQ KVA