ID   SYME_SALHS              Reviewed;         110 AA.
AC   B4TGA3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Endoribonuclease SymE {ECO:0000255|HAMAP-Rule:MF_01193};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01193};
GN   Name=symE {ECO:0000255|HAMAP-Rule:MF_01193}; OrderedLocusNames=SeHA_C4929;
OS   Salmonella heidelberg (strain SL476).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=454169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL476;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Involved in the degradation and recycling of damaged RNA. It
CC       is itself a target for degradation by the ATP-dependent protease Lon.
CC       {ECO:0000255|HAMAP-Rule:MF_01193}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01193}.
CC   -!- SIMILARITY: Belongs to the SymE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01193}.
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DR   EMBL; CP001120; ACF69668.1; -; Genomic_DNA.
DR   RefSeq; WP_001520547.1; NC_011083.1.
DR   AlphaFoldDB; B4TGA3; -.
DR   KEGG; seh:SeHA_C4929; -.
DR   HOGENOM; CLU_151239_0_0_6; -.
DR   OMA; MRQHTRT; -.
DR   Proteomes; UP000001866; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   HAMAP; MF_01193; Endoribonucl_SymE; 1.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR014944; Toxin_SymE-like.
DR   InterPro; IPR020883; TypeI_TA_SymE.
DR   Pfam; PF08845; SymE_toxin; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease; RNA-binding.
FT   CHAIN           1..110
FT                   /note="Endoribonuclease SymE"
FT                   /id="PRO_1000138402"
FT   DOMAIN          29..74
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ   SEQUENCE   110 AA;  12154 MW;  9185B7F409CBA840 CRC64;
     MTTVHSIADP CDPEVSPTNN RHLTVSYASR YPDYTRIPAL TMKGQWLEAA GFATGTEVDV
     RVMNGCIVLT AQQPQPEESE LMQSLRQVSK LSARKQKQVQ AFIDVMAGSK