SYMM_NEUCR
ID SYMM_NEUCR Reviewed; 622 AA.
AC Q9C2H9; Q7RV17;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable methionine--tRNA ligase, mitochondrial;
DE EC=6.1.1.10;
DE AltName: Full=Methionyl-tRNA synthetase;
DE Short=MetRS;
GN ORFNames=93G11.130, NCU03759;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC ChEBI:CHEBI:456215; EC=6.1.1.10;
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000305}.
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DR EMBL; AL513443; CAC28665.1; -; Genomic_DNA.
DR EMBL; CM002240; EAA31870.1; -; Genomic_DNA.
DR RefSeq; XP_961106.1; XM_956013.2.
DR AlphaFoldDB; Q9C2H9; -.
DR SMR; Q9C2H9; -.
DR STRING; 5141.EFNCRP00000003450; -.
DR EnsemblFungi; EAA31870; EAA31870; NCU03759.
DR GeneID; 3877271; -.
DR KEGG; ncr:NCU03759; -.
DR VEuPathDB; FungiDB:NCU03759; -.
DR HOGENOM; CLU_009710_9_0_1; -.
DR InParanoid; Q9C2H9; -.
DR OMA; MDTQAFC; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IBA:GO_Central.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR43326; PTHR43326; 1.
DR Pfam; PF19303; Anticodon_3; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; SSF47323; 1.
DR TIGRFAMs; TIGR00398; metG; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Ligase; Mitochondrion;
KW Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT CHAIN 1..622
FT /note="Probable methionine--tRNA ligase, mitochondrial"
FT /id="PRO_0000139271"
FT REGION 592..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 67..79
FT /note="'HIGH' region"
FT MOTIF 366..370
FT /note="'KMSKS' region"
FT COMPBIAS 607..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 369
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 622 AA; 70623 MW; 45E81CBA3ABDAE4E CRC64;
MDVLRTASAR RTFKWQAAGI LARTSWVCRS CRSQFVAPKA ARRTLATSTT TTTPTAPDNK
PFYVTTPIFY VNASPHVGHM YSMVLGDVLK RWQTLKGNQA ILCTGTDEHG TKVQRAAIAN
DMDPKQFCDL NSAKFQELAA ACRIDYDRFM RTTDQDHVEA VKHFWLLLKE KGLIYEAKHE
GWYCVSDECF YPESQLEKRQ DPFTGEVYVA SIESGNKVEW IEEKNYHFRM TALKDQLLEF
YKNNPDWIVP QTRMNQVVDW VTNNLEDLSI SRPVSRLSWG IRVPDDESQT IYVWVDALIN
YITMAGYPYW PPGREHLGGW PVDVHVIGKD ILRFHCIYWP ALLLALDLPL PKRILSHAHW
TMEKKKMSKS IGNVVNPFYA MERFGIDTMR FYMIHNGGIA NDADYSNDWL TVEYKKHLQN
GVGNLSARVT RPKQWSLRRA VQSYQDGNML LQSTGEQIND SCVEHITRLD KLASTIDNEM
LQLNPSHALQ KIMGLIGETN AFISNAEPWV IVKKQDSEAL VDRIILTAGE SLRIAGILLQ
PFMPDKAAQL LDLLGVENHN RTFHHARPLV DATYGTAFRT FGKEGIFPPP ILDDIKGMGP
DAGSKKHSSG NKPSSGNKKP TA