BM068_DROME
ID BM068_DROME Reviewed; 40 AA.
AC A1ZB64; F2FBA7;
DT 11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Bomanin-068 {ECO:0000303|PubMed:25915418, ECO:0000312|FlyBase:FBgn0040733};
DE Flags: Precursor;
GN Name=Bom068 {ECO:0000312|EMBL:AAN16134.1};
GN ORFNames=CG15068 {ECO:0000312|FlyBase:FBgn0040733};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AEA77308.1, ECO:0000312|EMBL:ANY27678.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Booth B., Calderwood M., Carlson J., Celniker S., Frise E., Hao T., Hu Y.,
RA Hill D., Yu C., Mohr S., Park S., Perrimon N., Spirohn K., Vidal M.,
RA Wan K.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=25915418; DOI=10.1371/journal.ppat.1004876;
RA Clemmons A.W., Lindsay S.A., Wasserman S.A.;
RT "An effector Peptide family required for Drosophila toll-mediated
RT immunity.";
RL PLoS Pathog. 11:E1004876-E1004876(2015).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=29920489; DOI=10.1159/000489831;
RA Lindsay S.A., Lin S.J.H., Wasserman S.A.;
RT "Short-Form Bomanins Mediate Humoral Immunity in Drosophila.";
RL J. Innate Immun. 10:306-314(2018).
CC -!- FUNCTION: Secreted immune-induced peptide induced by Toll signaling.
CC Has a role in resistance to bacterial and fungal infections
CC (PubMed:25915418, PubMed:29920489). The strength of antimicrobial
CC activity appears to correlate with the overall level of expression
CC (PubMed:29920489). {ECO:0000269|PubMed:25915418,
CC ECO:0000269|PubMed:29920489}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P82706}.
CC -!- SIMILARITY: Belongs to the bomanin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEA77308.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAN16134.1; -; Genomic_DNA.
DR EMBL; BT126194; AEA77308.1; ALT_INIT; mRNA.
DR EMBL; KX531868; ANY27678.1; -; mRNA.
DR RefSeq; NP_788402.1; NM_176222.2.
DR AlphaFoldDB; A1ZB64; -.
DR IntAct; A1ZB64; 2.
DR STRING; 7227.FBpp0085906; -.
DR PaxDb; A1ZB64; -.
DR DNASU; 50206; -.
DR EnsemblMetazoa; FBtr0086727; FBpp0085906; FBgn0040733.
DR GeneID; 50206; -.
DR KEGG; dme:Dmel_CG15068; -.
DR UCSC; CG15068-RA; d. melanogaster.
DR CTD; 50206; -.
DR FlyBase; FBgn0040733; Bom068.
DR VEuPathDB; VectorBase:FBgn0040733; -.
DR eggNOG; ENOG502T9FY; Eukaryota.
DR HOGENOM; CLU_204809_0_0_1; -.
DR InParanoid; A1ZB64; -.
DR PhylomeDB; A1ZB64; -.
DR BioGRID-ORCS; 50206; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 50206; -.
DR PRO; PR:A1ZB64; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0040733; Expressed in head capsule and 21 other tissues.
DR Genevisible; A1ZB64; DM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR013172; Bomanin.
DR Pfam; PF08194; DIM; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Immunity; Innate immunity; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..23
FT /note="Removed by a dipeptidylpeptidase"
FT /evidence="ECO:0000250|UniProtKB:P82706"
FT /id="PRO_0000448690"
FT PEPTIDE 24..40
FT /note="Bomanin-068"
FT /evidence="ECO:0000250|UniProtKB:P82706"
FT /id="PRO_0000448691"
FT DISULFID 32..35
FT /evidence="ECO:0000250|UniProtKB:P82706"
SQ SEQUENCE 40 AA; 4190 MW; 9E4942E4FC2E4894 CRC64;
MKLLSITFLF GLLALASANP LSPGNVIING DCKVCNIRGD
