ID   BM1LA_DANRE             Reviewed;         323 AA.
AC   Q4V8V1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Breast cancer metastasis-suppressor 1-like protein-A;
GN   Name=brms1la; Synonyms=brms1l; ORFNames=zgc:114129;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the histone deacetylase (HDAC1)-dependent
CC       transcriptional repression activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRMS1 family. {ECO:0000305}.
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DR   EMBL; BC097187; AAH97187.1; -; mRNA.
DR   RefSeq; NP_001025273.1; NM_001030102.2.
DR   AlphaFoldDB; Q4V8V1; -.
DR   SMR; Q4V8V1; -.
DR   STRING; 7955.ENSDARP00000008214; -.
DR   PaxDb; Q4V8V1; -.
DR   Ensembl; ENSDART00000003418; ENSDARP00000008214; ENSDARG00000006235.
DR   GeneID; 792017; -.
DR   KEGG; dre:792017; -.
DR   CTD; 792017; -.
DR   ZFIN; ZDB-GENE-050913-49; brms1la.
DR   eggNOG; KOG4466; Eukaryota.
DR   GeneTree; ENSGT00940000164711; -.
DR   HOGENOM; CLU_050862_2_0_1; -.
DR   InParanoid; Q4V8V1; -.
DR   OrthoDB; 1456563at2759; -.
DR   PhylomeDB; Q4V8V1; -.
DR   TreeFam; TF323740; -.
DR   PRO; PR:Q4V8V1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000006235; Expressed in swim bladder and 21 other tissues.
DR   ExpressionAtlas; Q4V8V1; baseline.
DR   GO; GO:0070822; C:Sin3-type complex; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013907; Sds3.
DR   PANTHER; PTHR21964; PTHR21964; 1.
DR   Pfam; PF08598; Sds3; 1.
DR   SMART; SM01401; Sds3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..323
FT                   /note="Breast cancer metastasis-suppressor 1-like protein-
FT                   A"
FT                   /id="PRO_0000305312"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          50..81
FT                   /evidence="ECO:0000255"
FT   COILED          156..178
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..48
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  37610 MW;  9D7FFADE6A03643D CRC64;
     MPVHSREKKE SNHEEMEVDF AEQEGSSSED EDTESSSVSE DGESSEMDDE DCERRRMECI
     DEMTNLEKQF TDLKDQLYKE RLNQVDAKLQ EVMSGKAAEY LEPLATLQEN MQIRTKVAGI
     YRELCLESVK NKYDCETQAA FQHWESEKLL LFDTVQTELE EKIRRLEEDR HSIDITSELW
     NDELQSRKNK KKDPFSPDKK KKPVVVSGPY IVYMLQDLDI LEDWTAIRKA MATLGPHRVK
     TDASSKIDKL QHNARSEDGR LFYDGEWYSR GQAITIDKKD EYPTSAVITT INHDEVWFKR
     VDGSKSKLYV SQLQKGKYTV KHA