BM836_DROME
ID BM836_DROME Reviewed; 76 AA.
AC A1ZB62; D4G7G1;
DT 11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Bomanin-836 {ECO:0000303|PubMed:29920489, ECO:0000312|FlyBase:FBgn0040735};
DE Flags: Precursor;
GN Name=Bom836 {ECO:0000303|PubMed:29920489, ECO:0000312|FlyBase:FBgn0040735};
GN ORFNames=CG16836 {ECO:0000312|FlyBase:FBgn0040735};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ADE06719.1, ECO:0000312|EMBL:ANY27303.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Booth B., Calderwood M., Carlson J., Celniker S., Frise E., Hao T., Hu Y.,
RA Hill D., Yu C., Mohr S., Park S., Perrimon N., Spirohn K., Vidal M.,
RA Wan K.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION.
RX PubMed=25915418; DOI=10.1371/journal.ppat.1004876;
RA Clemmons A.W., Lindsay S.A., Wasserman S.A.;
RT "An effector Peptide family required for Drosophila toll-mediated
RT immunity.";
RL PLoS Pathog. 11:E1004876-E1004876(2015).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=29920489; DOI=10.1159/000489831;
RA Lindsay S.A., Lin S.J.H., Wasserman S.A.;
RT "Short-Form Bomanins Mediate Humoral Immunity in Drosophila.";
RL J. Innate Immun. 10:306-314(2018).
CC -!- FUNCTION: Secreted immune-induced peptide induced by Toll signaling
CC (PubMed:25915418, PubMed:29920489). Has a role in resistance to
CC bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The
CC strength of antimicrobial activity appears to correlate with the
CC overall level of expression (PubMed:29920489).
CC {ECO:0000269|PubMed:25915418, ECO:0000269|PubMed:29920489}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P82706}.
CC -!- SIMILARITY: Belongs to the bomanin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ADE06719.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF57706.1; -; Genomic_DNA.
DR EMBL; BT122113; ADE06719.1; ALT_INIT; mRNA.
DR EMBL; KX531493; ANY27303.1; -; mRNA.
DR RefSeq; NP_652367.1; NM_144110.2.
DR AlphaFoldDB; A1ZB62; -.
DR IntAct; A1ZB62; 3.
DR STRING; 7227.FBpp0085847; -.
DR PaxDb; A1ZB62; -.
DR DNASU; 50208; -.
DR EnsemblMetazoa; FBtr0086666; FBpp0085847; FBgn0040735.
DR GeneID; 50208; -.
DR KEGG; dme:Dmel_CG16836; -.
DR UCSC; CG16836-RA; d. melanogaster.
DR CTD; 50208; -.
DR FlyBase; FBgn0040735; Bom836.
DR VEuPathDB; VectorBase:FBgn0040735; -.
DR eggNOG; ENOG502T99X; Eukaryota.
DR HOGENOM; CLU_2673718_0_0_1; -.
DR InParanoid; A1ZB62; -.
DR OMA; CNRPDGD; -.
DR OrthoDB; 1613755at2759; -.
DR PhylomeDB; A1ZB62; -.
DR BioGRID-ORCS; 50208; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 50208; -.
DR PRO; PR:A1ZB62; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0040735; Expressed in capitellum (Drosophila) and 20 other tissues.
DR Genevisible; A1ZB62; DM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR013172; Bomanin.
DR Pfam; PF08194; DIM; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Immunity; Innate immunity; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250|UniProtKB:P82706"
FT PROPEP 23..24
FT /note="Removed by a dipeptidylpeptidase"
FT /evidence="ECO:0000250|UniProtKB:P82706"
FT /id="PRO_0000448692"
FT PEPTIDE 25..76
FT /note="Bomanin-836"
FT /evidence="ECO:0000250|UniProtKB:P82706"
FT /id="PRO_0000448693"
FT DISULFID 33..36
FT /evidence="ECO:0000250|UniProtKB:P82706"
SQ SEQUENCE 76 AA; 8090 MW; EF3BEF5DAEFFEA16 CRC64;
MKALQVAGTL MLLFCLLAAV NATPGQVYIN GKCIDCNKPD NDPGIIIPPD HKSAGSMSYT
LTSGAIFFGI IYHIFS
