ABPF_DICDI
ID ABPF_DICDI Reviewed; 2364 AA.
AC Q54ET6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Actin-binding protein F;
GN Name=abpF; Synonyms=kenN; ORFNames=DDB_0230207;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP ACTIN-BINDING, AND SUBCELLULAR LOCATION.
RA Niebling K.R.;
RL Thesis (1993), Standford University, United States.
RN [3]
RP PROTEIN SEQUENCE OF 364-372; 537-548; 850-862; 1040-1052 AND 1356-1371, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=AX2;
RA Bienvenut W.V., Ura S., Insall R.H.;
RL Submitted (JUL-2009) to UniProtKB.
CC -!- SUBUNIT: Interacts with actin.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|Ref.2}. Cytoplasm,
CC cytoskeleton {ECO:0000269|Ref.2}. Note=localizes at the centrosome.
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DR EMBL; AAFI02000177; EAL61598.1; -; Genomic_DNA.
DR RefSeq; XP_635154.1; XM_630062.1.
DR AlphaFoldDB; Q54ET6; -.
DR PaxDb; Q54ET6; -.
DR EnsemblProtists; EAL61598; EAL61598; DDB_G0291229.
DR GeneID; 8628100; -.
DR KEGG; ddi:DDB_G0291229; -.
DR dictyBase; DDB_G0291229; abpF.
DR eggNOG; ENOG502QT0W; Eukaryota.
DR HOGENOM; CLU_230958_0_0_1; -.
DR InParanoid; Q54ET6; -.
DR OMA; LVNSRTH; -.
DR PRO; PR:Q54ET6; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleus;
KW Reference proteome.
FT CHAIN 1..2364
FT /note="Actin-binding protein F"
FT /id="PRO_0000388373"
FT REGION 138..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1929..2088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1960..2017
FT /evidence="ECO:0000255"
FT COILED 2129..2173
FT /evidence="ECO:0000255"
FT COMPBIAS 138..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1412..1429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1929..1959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1960..2016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2017..2053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2054..2070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2364 AA; 269778 MW; 64C12F4868180943 CRC64;
MTVSNNKKFE ENYVLASDIE EKEKLLGTLI GGSPQYFYYN VIHLLNVDPT LSDSKNREKY
QKLMKDWSPE SKPIPVTPYG GNNNYESTQQ YKSVDLRQKL LSFRQDNVNP SALANNVNDM
FEELRYLLSL TFSYTQTTHQ TSPTTETTTT PSSSSSSSHD DKSESTLDES LVNKKTVIES
IINQYPYKVD YISPNSFEYV LNNFTLPESA EKSIVQKLKY PIVPNDKLQQ LLSHHKGSFG
SLKIHENLTL EQMEKHIEKN PEHLDSAYVK LYLEKLLPTN ELHDWETLKP VQEQFYQSAS
KFVSNLPTSL NTFKLLIYHH YIKFQISDNK YDQSIIEKYF QLPRDTYYYV EPDRLKSNPQ
LSKFNDSFNG LKSVSQDDDE KLISFLLKKL FLKENSIKSY QSYFRPNYLN LILAESKLLS
NDSSPEKWIE MIDNHTKVQE LKDRVDIEFL PTNREYYHPD DDVVIECAIK NVNTLLVKVF
EISTFNYYKS ENKKIDSNIN LDGLIASQEL SFDYSEQAPI EKVEKKFDFP NLKGKRGIFV
IEFIGNGKSS RSMIQKGDLH FIVETSPIGQ VIKIIDQDSI KVQKSSVYID GNAYNSNDDG
DIKIPFSSST SQKSIILMAK IGDSDVFASL KKFTHQSEHY SLSGGIFVEN SSLLQNEKAP
IVVRVKLFLG DTQISNNYLE EPSLTITSSD NSESPVVNSK EIKPFALFDN KESVYQYKVQ
EGLNSLTVRF EAKVRALSRN NNQETLSFES TFQVNTINQT DQISEFYLER CLAKDGCSLG
YQLCHLGKGG DPFSHLDVSM DFQHWLTSER IYTTLKTDKN GKIHLGSLAD IEQLNVNGSY
ATFNFPIKRQ QQFTYPSQIN IKLGETIRLP YLGNEKSVSH SQINFFQLGG VDDRNFVVHD
LLKKSVTIEN KNELLINGLG VGRYLLILAG SIQSSNTVEI LIDVVDGQFR EGYLVGPSRI
VSYNESNVKS LFFDTNIDTK HNQLQVKFKN HSPSTRVHVF SSYFEPTNSL NSSLSLSRGT
SQSYQEYSVK PKSLYFNGRS LGDEVNYILN RKTSKKLLPG NSLKKPSLLV QPWSIGKTTN
STNTLKQASK YNESEVKDEK SMRNRQVEKR RVSSTNRSPF LEFLSHPSIL LLNLEPSSTD
GIVNIDLSQL VEAGSTIHIH AVDNDSIFTK EIVISDPSSS SSINHFKDTK LVRPLDSSLH
YKEEKLITTV EPNSPFEILN VNSSKYTVYD SLDKVLSLMK TLNKSYLQDF SFIAEWESLS
FEKKKEKFSK FTCHELNFFI YKKDKEFFDQ VVLPLVQTKG YKTFIDHYLC ADRKKLEIFV
IDSNRFNTLN ALEMVLLGEL FPEHSDSISN LLKQKVGFSP ISPSQYDTNF KIALNQLDTD
IESLKSGDDD LYDDGSNLEP MSVGGGGGFG YNNNSNNNNN TTNSNSFGDA KRAPMKKKMV
NKESTSLMMD CAAPMMMMAS APCPAPGAVP MAALRSARLA SASPAPPAPI TRAYEAAQIY
QPIEKTEELA ETYYYKQLNP HSSLIPVNEF WLDYANHIKS QSKTPFVSKY IAFISSSFAE
SMMALSVLDF PFTVKDNTTQ VRPKNGKLSM KPTTPIVVFH QELVSGSIEK QSDILVTQHF
FDPQNQFTYI DGEQEELYIN DQFLVSKVYG AMVVIANLSS KQKKLDALLE IPKGSIAVGP
SPFVTRSKSV NLSAYSTTRL QYYFYFPEAG KFPHFPAHVS EKQNIIANVT PFTFSVVLKP
SIVNHLSWEY IANQGTLESI LEYLSKNNLY RVDFYHLYHR YTDKKVWDKV IELLKKLKFY
ESITWSFSIH HKNFVYLKDY LSEQIHSLSM KSIDAPSIYV DPFENNFIKF LEYSPLVNSR
THQIGDERKI LNNKLSNQYY EFCSLLSLKL NPSDTELLSL AYYLLLQDRF DESIKIMKRI
GKHPVSIPKL ISSSTTTDSK STHSSVISSS SSSNLSTTTD SSKDKKKLEK EEKQREKERK
QKEKEDKKRE KEELKKKEKE EKKKKEEEKK LKKKSGSEAT SPSVDPATPT TTTTTEATTT
TTTTTATSQE SIKPEKIASD DEHDDHHHDE HDEEDDDDEP LIDMSEFNQP SCLPEMKVQY
DYLLSYLDFF NPNPTVAAEN SKKYENYPVQ RWNSLFKDLR NKVDQVSNKD SVEIDYEKEI
DRERRQNKMA SNEPTFDISS ESNRTISVNY SNLVDITVSY YVMDIEHLFS TNPFVQQELG
HFLYVTPNKK ESFLLKDKSG TFNFKIPNEF ANSNVVIDVV SAQIHHNITV YSNNLAVYIT
EKVGQLRVVH KQKSQPISKT YIKVYSKNKN GSVEFFKDGY TDIAGYFDYS TVSSLDISNV
SKLSILVLSN QYGAVIKEAK PPGF
