SYN1L_HUMAN
ID SYN1L_HUMAN Reviewed; 238 AA.
AC A6NDD5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Synapse differentiation-inducing gene protein 1-like;
DE AltName: Full=Capucin;
DE AltName: Full=Dispanin subfamily C member 1;
DE Short=DSPC1;
DE AltName: Full=Transmembrane protein 90A;
GN Name=SYNDIG1L; Synonyms=TMEM90A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP IDENTIFICATION.
RX PubMed=16359841; DOI=10.1016/j.ygeno.2005.10.009;
RA de Chaldee M., Brochier C., Van de Vel A., Caudy N., Luthi-Carter R.,
RA Gaillard M.-C., Elalouf J.-M.;
RT "Capucin: a novel striatal marker down-regulated in rodent models of
RT Huntington disease.";
RL Genomics 87:200-207(2006).
RN [3]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Golgi apparatus, cis-Golgi network
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR EMBL; AC005479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41970.1; -.
DR RefSeq; NP_001099049.1; NM_001105579.1.
DR RefSeq; XP_016877089.1; XM_017021600.1.
DR AlphaFoldDB; A6NDD5; -.
DR STRING; 9606.ENSP00000331474; -.
DR BioMuta; SYNDIG1L; -.
DR MassIVE; A6NDD5; -.
DR PaxDb; A6NDD5; -.
DR PRIDE; A6NDD5; -.
DR Antibodypedia; 55451; 9 antibodies from 5 providers.
DR DNASU; 646658; -.
DR Ensembl; ENST00000331628.8; ENSP00000331474.3; ENSG00000183379.9.
DR Ensembl; ENST00000554823.1; ENSP00000450439.1; ENSG00000183379.9.
DR GeneID; 646658; -.
DR KEGG; hsa:646658; -.
DR MANE-Select; ENST00000331628.8; ENSP00000331474.3; NM_001105579.2; NP_001099049.1.
DR UCSC; uc001xpx.2; human.
DR CTD; 646658; -.
DR DisGeNET; 646658; -.
DR GeneCards; SYNDIG1L; -.
DR HGNC; HGNC:32388; SYNDIG1L.
DR HPA; ENSG00000183379; Tissue enriched (brain).
DR MIM; 609999; gene.
DR neXtProt; NX_A6NDD5; -.
DR OpenTargets; ENSG00000183379; -.
DR PharmGKB; PA144596263; -.
DR VEuPathDB; HostDB:ENSG00000183379; -.
DR eggNOG; ENOG502QPQE; Eukaryota.
DR GeneTree; ENSGT00950000183147; -.
DR HOGENOM; CLU_094250_0_0_1; -.
DR InParanoid; A6NDD5; -.
DR OMA; NTNGKMK; -.
DR OrthoDB; 1273993at2759; -.
DR PhylomeDB; A6NDD5; -.
DR TreeFam; TF331357; -.
DR PathwayCommons; A6NDD5; -.
DR SignaLink; A6NDD5; -.
DR BioGRID-ORCS; 646658; 11 hits in 1058 CRISPR screens.
DR ChiTaRS; SYNDIG1L; human.
DR GenomeRNAi; 646658; -.
DR Pharos; A6NDD5; Tdark.
DR PRO; PR:A6NDD5; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; A6NDD5; protein.
DR Bgee; ENSG00000183379; Expressed in putamen and 108 other tissues.
DR ExpressionAtlas; A6NDD5; baseline and differential.
DR Genevisible; A6NDD5; HS.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..238
FT /note="Synapse differentiation-inducing gene protein 1-
FT like"
FT /id="PRO_0000332725"
FT TOPO_DOM 1..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..146
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 25796 MW; E2561A965A75C459 CRC64;
MESLSELQNP LLPRSPAHLH GPYPYPETPP SWSCQEKLYS YLLGGAGPAG AHQLLDPGSL
QLAVEAWYRP SCLLGRDKVK EPRAGSCETS FTEDREPQEG PPEQPTGPGQ AAENVTIQTV
SYGVQEELRD QEDDQEEEES DATSTESESE DNFLTLPPRD HLGLTLFSML CCFWPLGIAA
FYFSQGTSKA ISKGDFRLAS TTSRRALFLA TLAIAVGAGL YVAVVVALAA YMSQNGHG
