SYN1L_MOUSE
ID SYN1L_MOUSE Reviewed; 237 AA.
AC Q3USQ7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Synapse differentiation-inducing gene protein 1-like;
DE AltName: Full=Capucin;
DE AltName: Full=Caudate and putamen-enriched protein;
DE AltName: Full=Dispanin subfamily C member 1;
DE Short=DSPC1;
DE AltName: Full=Synapse differentiation-induced protein 2;
DE AltName: Full=Transmembrane protein 90A;
GN Name=Syndig1l; Synonyms=Gm261, SynDIG2, Tmem90a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum;
RX PubMed=16359841; DOI=10.1016/j.ygeno.2005.10.009;
RA de Chaldee M., Brochier C., Van de Vel A., Caudy N., Luthi-Carter R.,
RA Gaillard M.-C., Elalouf J.-M.;
RT "Capucin: a novel striatal marker down-regulated in rodent models of
RT Huntington disease.";
RL Genomics 87:200-207(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Golgi apparatus, cis-Golgi network
CC {ECO:0000269|PubMed:16359841}.
CC -!- TISSUE SPECIFICITY: Expression is restricted to the caudate-putamen.
CC Down-regulated in R6/2 transgenic mice, a model for Huntington disease.
CC {ECO:0000269|PubMed:16359841}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR EMBL; AY993933; AAY42815.1; -; mRNA.
DR EMBL; AY993934; AAY42816.1; -; mRNA.
DR EMBL; AK140195; BAE24274.1; -; mRNA.
DR EMBL; BC132221; AAI32222.1; -; mRNA.
DR CCDS; CCDS26049.1; -.
DR RefSeq; NP_001028506.1; NM_001033334.2.
DR RefSeq; XP_006516187.1; XM_006516124.3.
DR RefSeq; XP_006516188.1; XM_006516125.3.
DR AlphaFoldDB; Q3USQ7; -.
DR SMR; Q3USQ7; -.
DR STRING; 10090.ENSMUSP00000093206; -.
DR PaxDb; Q3USQ7; -.
DR PRIDE; Q3USQ7; -.
DR ProteomicsDB; 263174; -.
DR Antibodypedia; 55451; 9 antibodies from 5 providers.
DR Ensembl; ENSMUST00000095550; ENSMUSP00000093206; ENSMUSG00000071234.
DR Ensembl; ENSMUST00000222422; ENSMUSP00000152374; ENSMUSG00000071234.
DR GeneID; 627191; -.
DR KEGG; mmu:627191; -.
DR UCSC; uc007ofr.1; mouse.
DR CTD; 646658; -.
DR MGI; MGI:2685107; Syndig1l.
DR VEuPathDB; HostDB:ENSMUSG00000071234; -.
DR eggNOG; ENOG502QPQE; Eukaryota.
DR GeneTree; ENSGT00950000183147; -.
DR HOGENOM; CLU_094250_0_0_1; -.
DR InParanoid; Q3USQ7; -.
DR OMA; NTNGKMK; -.
DR OrthoDB; 1273993at2759; -.
DR PhylomeDB; Q3USQ7; -.
DR TreeFam; TF331357; -.
DR BioGRID-ORCS; 627191; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q3USQ7; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3USQ7; protein.
DR Bgee; ENSMUSG00000071234; Expressed in caudate-putamen and 85 other tissues.
DR ExpressionAtlas; Q3USQ7; baseline and differential.
DR Genevisible; Q3USQ7; MM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..237
FT /note="Synapse differentiation-inducing gene protein 1-
FT like"
FT /id="PRO_0000332726"
FT TOPO_DOM 1..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 25524 MW; 6D14F1EC48E7BE40 CRC64;
MESLSELQNP LLPRSPTHLH RPYPYPEAPP GWSCQEQLYS FLLGGAGPAR AHQLLDPGSL
QLAVEAWYRP SCLLGRDKVK EPKAGSCETS FTEAREPLAG PAEEGSEPGQ AAEDVTIHTV
SYGVQEELQG QEDSQEEESD GTSSESECED AFLTLPPRDH LGLTLFSMLC CFWPLGIAAF
YFSQGTSKAI SKGDFRLAST TSRRALFLAT LSIAVGAGLY VAVVVALAAY MSQNGHG
