BMCP_DROME
ID BMCP_DROME Reviewed; 303 AA.
AC Q7K566;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Mitochondrial uncoupling protein Bmcp {ECO:0000305};
DE AltName: Full=Brain mitochondrial carrier protein 1 {ECO:0000303|PubMed:15337852};
DE Short=Bmcp-1 {ECO:0000303|PubMed:15337852};
DE AltName: Full=Mitochondrial uncoupling protein 5 {ECO:0000305|PubMed:15337852};
GN Name=Bmcp {ECO:0000312|FlyBase:FBgn0036199};
GN Synonyms=Ucp5 {ECO:0000303|PubMed:15337852};
GN ORFNames=CG7314 {ECO:0000312|FlyBase:FBgn0036199};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAK92857.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAK92857.1};
RC TISSUE=Head {ECO:0000312|EMBL:AAK92857.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15337852; DOI=10.1023/b:jobb.0000031973.20153.c6;
RA Fridell Y.W., Sanchez-Blanco A., Silvia B.A., Helfand S.L.;
RT "Functional characterization of a Drosophila mitochondrial uncoupling
RT protein.";
RL J. Bioenerg. Biomembr. 36:219-228(2004).
RN [5] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16387864; DOI=10.1534/genetics.105.053389;
RA Sanchez-Blanco A., Fridell Y.W., Helfand S.L.;
RT "Involvement of Drosophila uncoupling protein 5 in metabolism and aging.";
RL Genetics 172:1699-1710(2006).
CC -!- FUNCTION: Regulates metabolic homeostasis in response to nutritional
CC cues and may therefore be involved in adaptation to dietary variations.
CC May not function in creating mitochondrial proton leaks across the
CC inner mitochondrial membrane (i.e. mitochondrial uncoupling).
CC {ECO:0000269|PubMed:16387864}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expression levels are higher in the head than the
CC body. {ECO:0000269|PubMed:15337852}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development. Expression
CC levels are very weak, but increase in the adult stages.
CC {ECO:0000269|PubMed:15337852}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Reduced levels of total
CC sugars (glucose and trehalose) in normal-fed flies and increased
CC susceptibility to starvation. Life span is increased when fed a low-
CC calorie diet and flies gain less weight when fed a high-calorie diet.
CC Females lay a lower proportion of eggs, particularly under a restricted
CC diet. Glycogen and triacylglyceride (TAG) levels are not affected in
CC normal-fed flies. However, TAG levels decrease at a faster rate under
CC starvation conditions. No increase in life span when fed a high-calorie
CC diet or under starvation conditions. {ECO:0000269|PubMed:16387864}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- CAUTION: Functions as a mitochondrial uncoupling protein when expressed
CC in yeast. {ECO:0000269|PubMed:15337852}.
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DR EMBL; AE014296; AAF50019.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN11881.1; -; Genomic_DNA.
DR EMBL; AY051433; AAK92857.1; -; mRNA.
DR RefSeq; NP_648501.1; NM_140244.5.
DR RefSeq; NP_729738.1; NM_168472.2.
DR AlphaFoldDB; Q7K566; -.
DR SMR; Q7K566; -.
DR STRING; 7227.FBpp0075846; -.
DR PaxDb; Q7K566; -.
DR PRIDE; Q7K566; -.
DR DNASU; 39322; -.
DR EnsemblMetazoa; FBtr0076114; FBpp0075845; FBgn0036199.
DR EnsemblMetazoa; FBtr0076115; FBpp0075846; FBgn0036199.
DR GeneID; 39322; -.
DR KEGG; dme:Dmel_CG7314; -.
DR UCSC; CG7314-RA; d. melanogaster.
DR CTD; 39322; -.
DR FlyBase; FBgn0036199; Bmcp.
DR VEuPathDB; VectorBase:FBgn0036199; -.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000173356; -.
DR HOGENOM; CLU_015166_14_2_1; -.
DR InParanoid; Q7K566; -.
DR OMA; VWSNIIC; -.
DR OrthoDB; 1126848at2759; -.
DR PhylomeDB; Q7K566; -.
DR Reactome; R-DME-167826; The fatty acid cycling model.
DR Reactome; R-DME-167827; The proton buffering model.
DR BioGRID-ORCS; 39322; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39322; -.
DR PRO; PR:Q7K566; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036199; Expressed in cleaving embryo and 27 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0019222; P:regulation of metabolic process; IMP:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..303
FT /note="Mitochondrial uncoupling protein Bmcp"
FT /id="PRO_0000438778"
FT TRANSMEM 10..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..297
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 8..97
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 111..196
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 203..303
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 303 AA; 33493 MW; E52A93E2A2E5AC48 CRC64;
MGEVKDWRPF VYGGVASITA EFGTFPIDTT KTRLQIQGQK IDQSFSQLRY RGMTDAFVKI
SREEGLRALY SGIWPAVLRQ ATYGTIKFGT YYTLKKLANE RGLLINEDGS ERVWSNILCA
AAAGAISSAI ANPTDVLKVR MQVHGKGQHK GLLGCFGEIY KYEGVRGLWR GVGPTAQRAV
VIASVELPVY DFCKLQLMNA FGDHVGNHFI SSFIASLGSA IASTPIDVIR TRLMNQRPVS
ITMNGVVTAA ATPKLYSGSL DCAVQTIRNE GLPALYKGFI PTWVRMGPWN IIFFITYEQL
KKY
