SYNE4_HUMAN
ID SYNE4_HUMAN Reviewed; 404 AA.
AC Q8N205; A8MRS0; A8MYE3; Q7Z7L3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Nesprin-4;
DE AltName: Full=KASH domain-containing protein 4;
DE Short=KASH4;
DE AltName: Full=Nuclear envelope spectrin repeat protein 4;
GN Name=SYNE4; Synonyms=C19orf46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT HIS-278.
RC TISSUE=Mammary carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INVOLVEMENT IN DFNB76, AND SUBCELLULAR LOCATION.
RX PubMed=23348741; DOI=10.1172/jci66911;
RA Horn H.F., Brownstein Z., Lenz D.R., Shivatzki S., Dror A.A.,
RA Dagan-Rosenfeld O., Friedman L.M., Roux K.J., Kozlov S., Jeang K.T.,
RA Frydman M., Burke B., Stewart C.L., Avraham K.B.;
RT "The LINC complex is essential for hearing.";
RL J. Clin. Invest. 123:740-750(2013).
CC -!- FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and
CC Cytoskeleton) complex, involved in the connection between the nuclear
CC lamina and the cytoskeleton. The nucleocytoplasmic interactions
CC established by the LINC complex play an important role in the
CC transmission of mechanical forces across the nuclear envelope and in
CC nuclear movement and positioning (By similarity). Behaves as a kinesin
CC cargo, providing a functional binding site for kinesin-1 at the nuclear
CC envelope. Hence may contribute to the establishment of secretory
CC epithelial morphology by promoting kinesin-dependent apical migration
CC of the centrosome and Golgi apparatus and basal localization of the
CC nucleus (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Core component of LINC complexes which are composed of inner
CC nuclear membrane SUN domain-containing proteins coupled to outer
CC nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-
CC containing proteins seem to bind each other promiscuously; however,
CC differentially expression of LINC complex constituents can give rise to
CC specific assemblies (By similarity). Probably part of a SUN1-containing
CC LINC complex. Interacts with kinesins KIF5B and KLC1 (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N205; Q9ULW3: ABT1; NbExp=3; IntAct=EBI-7131783, EBI-2602396;
CC Q8N205; A8K660: ADIPOQ; NbExp=3; IntAct=EBI-7131783, EBI-10174479;
CC Q8N205; Q6PL45: BRICD5; NbExp=3; IntAct=EBI-7131783, EBI-10254180;
CC Q8N205; Q08722: CD47; NbExp=3; IntAct=EBI-7131783, EBI-1268321;
CC Q8N205; Q96LK0: CEP19; NbExp=3; IntAct=EBI-7131783, EBI-741885;
CC Q8N205; O95471: CLDN7; NbExp=3; IntAct=EBI-7131783, EBI-740744;
CC Q8N205; P56748: CLDN8; NbExp=3; IntAct=EBI-7131783, EBI-10215641;
CC Q8N205; Q9BXN2: CLEC7A; NbExp=7; IntAct=EBI-7131783, EBI-3939278;
CC Q8N205; Q96DZ9: CMTM5; NbExp=3; IntAct=EBI-7131783, EBI-2548702;
CC Q8N205; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-7131783, EBI-10267100;
CC Q8N205; Q07325: CXCL9; NbExp=3; IntAct=EBI-7131783, EBI-3911467;
CC Q8N205; Q5J5C9: DEFB121; NbExp=3; IntAct=EBI-7131783, EBI-10244198;
CC Q8N205; O60344: ECE2; NbExp=3; IntAct=EBI-7131783, EBI-3906484;
CC Q8N205; P56851: EDDM3B; NbExp=3; IntAct=EBI-7131783, EBI-10215665;
CC Q8N205; P54849: EMP1; NbExp=3; IntAct=EBI-7131783, EBI-4319440;
CC Q8N205; O75355: ENTPD3; NbExp=3; IntAct=EBI-7131783, EBI-10187968;
CC Q8N205; Q96D05: FAM241B; NbExp=3; IntAct=EBI-7131783, EBI-2548784;
CC Q8N205; Q969F0: FATE1; NbExp=5; IntAct=EBI-7131783, EBI-743099;
CC Q8N205; Q9Y287: ITM2B; NbExp=3; IntAct=EBI-7131783, EBI-2866431;
CC Q8N205; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-7131783, EBI-949319;
CC Q8N205; Q53G59: KLHL12; NbExp=3; IntAct=EBI-7131783, EBI-740929;
CC Q8N205; Q96E93: KLRG1; NbExp=3; IntAct=EBI-7131783, EBI-750770;
CC Q8N205; Q86UP2: KTN1; NbExp=3; IntAct=EBI-7131783, EBI-359761;
CC Q8N205; Q13021: MALL; NbExp=3; IntAct=EBI-7131783, EBI-750078;
CC Q8N205; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-7131783, EBI-10317612;
CC Q8N205; Q16625: OCLN; NbExp=3; IntAct=EBI-7131783, EBI-2903088;
CC Q8N205; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-7131783, EBI-2804156;
CC Q8N205; Q8TBU1: OSTCL; NbExp=3; IntAct=EBI-7131783, EBI-10273677;
CC Q8N205; Q9NXK6: PAQR5; NbExp=3; IntAct=EBI-7131783, EBI-10316423;
CC Q8N205; Q5TAB7: RIPPLY2; NbExp=3; IntAct=EBI-7131783, EBI-10246897;
CC Q8N205; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-7131783, EBI-8652744;
CC Q8N205; Q15437: SEC23B; NbExp=3; IntAct=EBI-7131783, EBI-742673;
CC Q8N205; Q9HC62: SENP2; NbExp=3; IntAct=EBI-7131783, EBI-714881;
CC Q8N205; P11686: SFTPC; NbExp=3; IntAct=EBI-7131783, EBI-10197617;
CC Q8N205; O00631: SLN; NbExp=3; IntAct=EBI-7131783, EBI-10180786;
CC Q8N205; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-7131783, EBI-8640191;
CC Q8N205; Q12893: TMEM115; NbExp=3; IntAct=EBI-7131783, EBI-8633987;
CC Q8N205; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-7131783, EBI-2844246;
CC Q8N205; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-7131783, EBI-348587;
CC Q8N205; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-7131783, EBI-10255122;
CC Q8N205; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-7131783, EBI-10314986;
CC Q8N205; Q9NRS4-3: TMPRSS4; NbExp=3; IntAct=EBI-7131783, EBI-10312990;
CC Q8N205; Q86WT6: TRIM69; NbExp=3; IntAct=EBI-7131783, EBI-749955;
CC Q8N205; O95858: TSPAN15; NbExp=3; IntAct=EBI-7131783, EBI-7361096;
CC Q8N205; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-7131783, EBI-10243654;
CC Q8N205; Q9UEU0: VTI1B; NbExp=4; IntAct=EBI-7131783, EBI-723716;
CC Q8N205; P15622-3: ZNF250; NbExp=3; IntAct=EBI-7131783, EBI-10177272;
CC Q8N205-2; Q15848: ADIPOQ; NbExp=6; IntAct=EBI-12099160, EBI-10827839;
CC Q8N205-2; Q96LK0: CEP19; NbExp=3; IntAct=EBI-12099160, EBI-741885;
CC Q8N205-2; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-12099160, EBI-12256978;
CC Q8N205-2; A0A0S2Z5K4: CSGALNACT2; NbExp=3; IntAct=EBI-12099160, EBI-16434756;
CC Q8N205-2; P24593: IGFBP5; NbExp=3; IntAct=EBI-12099160, EBI-720480;
CC Q8N205-2; Q13021: MALL; NbExp=3; IntAct=EBI-12099160, EBI-750078;
CC Q8N205-2; Q96CV9: OPTN; NbExp=3; IntAct=EBI-12099160, EBI-748974;
CC Q8N205-2; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-12099160, EBI-11721828;
CC Q8N205-2; P11686: SFTPC; NbExp=4; IntAct=EBI-12099160, EBI-10197617;
CC Q8N205-2; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-12099160, EBI-8640191;
CC Q8N205-2; Q15560: TCEA2; NbExp=3; IntAct=EBI-12099160, EBI-710310;
CC Q8N205-2; Q5T619: ZNF648; NbExp=3; IntAct=EBI-12099160, EBI-11985915;
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein
CC {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer
CC membrane requires the presence of SUN1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N205-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N205-2; Sequence=VSP_028444;
CC -!- DOMAIN: The KASH domain, which contains a transmembrane domain,
CC mediates the nuclear envelope targeting and is involved in the binding
CC to SUN1 and SUN2 through recognition of their SUN domains.
CC {ECO:0000250}.
CC -!- PTM: The disulfid bond with SUN1 or SUN2 is required for stability of
CC the respective LINC complex under tensile forces.
CC {ECO:0000250|UniProtKB:Q8WXH0}.
CC -!- DISEASE: Deafness, autosomal recessive, 76 (DFNB76) [MIM:615540]: A
CC form of non-syndromic sensorineural deafness, a disorder resulting from
CC damage to the neural receptors of the inner ear, the nerve pathways to
CC the brain, or the area of the brain that receives sound information.
CC DFNB76 affected individuals have onset of progressive high frequency
CC hearing impairment between birth and 6 years of age. The hearing loss
CC is severe at high frequencies by adulthood.
CC {ECO:0000269|PubMed:23348741}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the nesprin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04222.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AK093764; BAC04222.1; ALT_SEQ; mRNA.
DR EMBL; AC002116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF038458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052573; AAH52573.1; -; mRNA.
DR CCDS; CCDS42553.1; -. [Q8N205-1]
DR CCDS; CCDS77285.1; -. [Q8N205-2]
DR RefSeq; NP_001034965.1; NM_001039876.2. [Q8N205-1]
DR RefSeq; NP_001284664.1; NM_001297735.2. [Q8N205-2]
DR PDB; 6R16; X-ray; 2.75 A; G/H/I/J/K/L=376-404.
DR PDB; 6WMD; X-ray; 1.50 A; B=377-404.
DR PDBsum; 6R16; -.
DR PDBsum; 6WMD; -.
DR AlphaFoldDB; Q8N205; -.
DR SASBDB; Q8N205; -.
DR SMR; Q8N205; -.
DR BioGRID; 127856; 98.
DR IntAct; Q8N205; 90.
DR MINT; Q8N205; -.
DR STRING; 9606.ENSP00000316130; -.
DR iPTMnet; Q8N205; -.
DR PhosphoSitePlus; Q8N205; -.
DR BioMuta; SYNE4; -.
DR DMDM; 158706458; -.
DR EPD; Q8N205; -.
DR jPOST; Q8N205; -.
DR MassIVE; Q8N205; -.
DR MaxQB; Q8N205; -.
DR PaxDb; Q8N205; -.
DR PeptideAtlas; Q8N205; -.
DR PRIDE; Q8N205; -.
DR ProteomicsDB; 71647; -. [Q8N205-1]
DR ProteomicsDB; 71648; -. [Q8N205-2]
DR Antibodypedia; 34811; 103 antibodies from 18 providers.
DR DNASU; 163183; -.
DR Ensembl; ENST00000324444.9; ENSP00000316130.3; ENSG00000181392.17. [Q8N205-1]
DR Ensembl; ENST00000340477.9; ENSP00000343152.5; ENSG00000181392.17. [Q8N205-2]
DR GeneID; 163183; -.
DR KEGG; hsa:163183; -.
DR MANE-Select; ENST00000324444.9; ENSP00000316130.3; NM_001039876.3; NP_001034965.1.
DR UCSC; uc002ocq.2; human. [Q8N205-1]
DR CTD; 163183; -.
DR DisGeNET; 163183; -.
DR GeneCards; SYNE4; -.
DR HGNC; HGNC:26703; SYNE4.
DR HPA; ENSG00000181392; Low tissue specificity.
DR MalaCards; SYNE4; -.
DR MIM; 615535; gene.
DR MIM; 615540; phenotype.
DR neXtProt; NX_Q8N205; -.
DR OpenTargets; ENSG00000181392; -.
DR Orphanet; 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR PharmGKB; PA145149542; -.
DR VEuPathDB; HostDB:ENSG00000181392; -.
DR eggNOG; ENOG502SZGW; Eukaryota.
DR GeneTree; ENSGT00510000049061; -.
DR HOGENOM; CLU_034166_1_0_1; -.
DR InParanoid; Q8N205; -.
DR OMA; IRSEQAQ; -.
DR OrthoDB; 938875at2759; -.
DR PhylomeDB; Q8N205; -.
DR PathwayCommons; Q8N205; -.
DR SignaLink; Q8N205; -.
DR SIGNOR; Q8N205; -.
DR BioGRID-ORCS; 163183; 15 hits in 1074 CRISPR screens.
DR ChiTaRS; SYNE4; human.
DR GenomeRNAi; 163183; -.
DR Pharos; Q8N205; Tbio.
DR PRO; PR:Q8N205; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N205; protein.
DR Bgee; ENSG00000181392; Expressed in pancreatic ductal cell and 116 other tissues.
DR ExpressionAtlas; Q8N205; baseline and differential.
DR Genevisible; Q8N205; HS.
DR GO; GO:0031309; C:integral component of nuclear outer membrane; ISS:UniProtKB.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:InterPro.
DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; ISS:UniProtKB.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR030268; SYNE4.
DR PANTHER; PTHR21640; PTHR21640; 1.
DR Pfam; PF10541; KASH; 1.
DR SMART; SM01249; KASH; 1.
DR PROSITE; PS51049; KASH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Deafness; Disulfide bond; Membrane;
KW Non-syndromic deafness; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..404
FT /note="Nesprin-4"
FT /id="PRO_0000306264"
FT TOPO_DOM 1..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT TRANSMEM 356..376
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 377..404
FT /note="Perinuclear space"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT DOMAIN 347..404
FT /note="KASH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 381
FT /note="Interchain (with C-563 in SUN2); alternate"
FT /evidence="ECO:0000250|UniProtKB:Q8WXH0"
FT DISULFID 381
FT /note="Interchain (with C-657 in SUN1)"
FT /evidence="ECO:0000250|UniProtKB:Q8WXH0"
FT VAR_SEQ 94..206
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028444"
FT VARIANT 224
FT /note="S -> L (in dbSNP:rs34818970)"
FT /id="VAR_035284"
FT VARIANT 278
FT /note="Q -> H (in dbSNP:rs2285422)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035285"
FT STRAND 394..397
FT /evidence="ECO:0007829|PDB:6WMD"
SQ SEQUENCE 404 AA; 43512 MW; F15E209FB06636D2 CRC64;
MALSLPLGPR LGSEPLNHPP GAPREADIVG CTVCPASGEE STSPEQAQTL GQDSLGPPEH
FQGGPRGNEP AAHPPRWSTP SSYEDPAGGK HCEHPISGLE VLEAEQNSLH LCLLGLGRRL
QDLEQGLGHW ALAQSGMVQL QALQVDLRGA AERVEALLAF GEGLAQRSEP RAWAALEQIL
RALGAYRDSI FRRLWQLQAQ LVSYSLVFEE ANTLDQDLEV EGDSDWPGPG GVWGPWAPSS
LPTSTELEWD PAGDIGGLGP LGQKTARTLG VPCELCGQRG PQGRGQGLEE ADTSHSRQDM
LESGLGHQKR LARHQRHSLL RKPQDKKRQA SPHLQDVRLE GNPGAPDPAS RQPLTFLLIL
FLLFLLLVGA MFLLPASGGP CCSHARIPRT PYLVLSYVNG LPPV
