ID   SYNG1_BOVIN             Reviewed;         258 AA.
AC   Q08DM6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Synapse differentiation-inducing gene protein 1;
DE            Short=SynDIG1;
DE   AltName: Full=Dispanin subfamily C member 2;
DE            Short=DSPC2;
DE   AltName: Full=Transmembrane protein 90B;
GN   Name=SYNDIG1; Synonyms=TMEM90B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY.
RX   PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA   Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT   "The dispanins: a novel gene family of ancient origin that contains 14
RT   human members.";
RL   PLoS ONE 7:E31961-E31961(2012).
CC   -!- FUNCTION: May regulate AMPA receptor content at nascent synapses, and
CC       have a role in postsynaptic development and maturation. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with GRIA1 and GRIA2 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC       protein. Early endosome membrane {ECO:0000250}; Single-pass type II
CC       membrane protein {ECO:0000250}. Postsynaptic density membrane
CC       {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendrite
CC       {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}.
CC       Note=Shuttles between the cell surface and early endosome membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR   EMBL; BC123666; AAI23667.1; -; mRNA.
DR   RefSeq; NP_001069731.1; NM_001076263.1.
DR   RefSeq; XP_010809590.1; XM_010811288.2.
DR   RefSeq; XP_015329551.1; XM_015474065.1.
DR   AlphaFoldDB; Q08DM6; -.
DR   STRING; 9913.ENSBTAP00000051406; -.
DR   PaxDb; Q08DM6; -.
DR   PRIDE; Q08DM6; -.
DR   Ensembl; ENSBTAT00000054611; ENSBTAP00000051406; ENSBTAG00000040147.
DR   Ensembl; ENSBTAT00000082529; ENSBTAP00000057141; ENSBTAG00000040147.
DR   GeneID; 541217; -.
DR   KEGG; bta:541217; -.
DR   CTD; 79953; -.
DR   VEuPathDB; HostDB:ENSBTAG00000040147; -.
DR   VGNC; VGNC:35519; SYNDIG1.
DR   eggNOG; ENOG502QQXK; Eukaryota.
DR   GeneTree; ENSGT00950000183147; -.
DR   HOGENOM; CLU_094250_0_0_1; -.
DR   InParanoid; Q08DM6; -.
DR   OMA; LGSECCE; -.
DR   OrthoDB; 1273993at2759; -.
DR   TreeFam; TF331357; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000040147; Expressed in cerebellum and 65 other tissues.
DR   ExpressionAtlas; Q08DM6; baseline.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0044297; C:cell body; ISS:UniProtKB.
DR   GO; GO:0043198; C:dendritic shaft; ISS:UniProtKB.
DR   GO; GO:0043197; C:dendritic spine; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0060076; C:excitatory synapse; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0035254; F:glutamate receptor binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.
DR   GO; GO:0097091; P:synaptic vesicle clustering; ISS:UniProtKB.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Endosome; Membrane; Phosphoprotein;
KW   Postsynaptic cell membrane; Reference proteome; Signal-anchor; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..258
FT                   /note="Synapse differentiation-inducing gene protein 1"
FT                   /id="PRO_0000332728"
FT   TOPO_DOM        1..181
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        203..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         137
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q58DZ9"
SQ   SEQUENCE   258 AA;  28334 MW;  C45C4A5CC0190ED1 CRC64;
     MAGVVEQKSG LVRDKLGEAS KRNGLINTRS LVAESRDGLV SVYPAPQYQS CRVVGSVASA
     GPDGARNEPL QQLLDPSTLQ QSVESRYRPN LILYSESVLR PWGDGVAADC CETTFIEDRS
     PTKESLEYPD GKFIDLSPED IKIHTLSYDV EEEEEFQELE SDYSSDTESE DNFLVMPPRD
     HLGLSVFSML CCFWPLGIAA FYLSHETNKA VAKGDFHQAS TSSRRALFLA VLSITIGTGI
     YVGVAVALIA YLSKSNHL