SYNG1_MOUSE
ID SYNG1_MOUSE Reviewed; 258 AA.
AC A2ANU3;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Synapse differentiation-inducing gene protein 1;
DE Short=SynDIG1;
DE AltName: Full=Dispanin subfamily C member 2;
DE Short=DSPC2;
DE AltName: Full=Transmembrane protein 90B;
GN Name=Syndig1; Synonyms=Tmem90b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12408845; DOI=10.1016/s0896-6273(02)01016-4;
RA Diaz E., Ge Y., Yang Y.H., Loh K.C., Serafini T.A., Okazaki Y.,
RA Hayashizaki Y., Speed T.P., Ngai J., Scheiffele P.;
RT "Molecular analysis of gene expression in the developing pontocerebellar
RT projection system.";
RL Neuron 36:417-434(2002).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP TOPOLOGY, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INTERACTION WITH GRIA1 AND GRIA2.
RX PubMed=20152115; DOI=10.1016/j.neuron.2009.12.021;
RA Kalashnikova E., Lorca R.A., Kaur I., Barisone G.A., Li B., Ishimaru T.,
RA Trimmer J.S., Mohapatra D.P., Diaz E.;
RT "SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane
RT protein that regulates excitatory synapse development.";
RL Neuron 65:80-93(2010).
RN [7]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- FUNCTION: May regulate AMPA receptor content at nascent synapses, and
CC have a role in postsynaptic development and maturation. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with GRIA1 and GRIA2.
CC {ECO:0000269|PubMed:20152115}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20152115};
CC Single-pass type II membrane protein {ECO:0000269|PubMed:20152115}.
CC Early endosome membrane {ECO:0000269|PubMed:20152115}; Single-pass type
CC II membrane protein {ECO:0000269|PubMed:20152115}. Postsynaptic density
CC membrane {ECO:0000269|PubMed:20152115}. Synapse {ECO:0000250}. Cell
CC projection, dendrite {ECO:0000250}. Cell projection, dendritic spine
CC {ECO:0000250}. Note=Shuttles between the cell surface and early
CC endosome membrane.
CC -!- TISSUE SPECIFICITY: Brain-specific. Expressed in Purkinje neurons in
CC cerebellum. Also detected in the hippocampus. Found at excitatory
CC synapses and postsynaptic cells. {ECO:0000269|PubMed:12408845,
CC ECO:0000269|PubMed:20152115}.
CC -!- DEVELOPMENTAL STAGE: Expressed during synaptogenesis. Found at the cell
CC surface of excitatory synapses. {ECO:0000269|PubMed:20152115}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR EMBL; AL831742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL28557.1; -; Genomic_DNA.
DR EMBL; BC147352; AAI47353.1; -; mRNA.
DR EMBL; BC147353; AAI47354.1; -; mRNA.
DR EMBL; BC147660; AAI47661.1; -; mRNA.
DR EMBL; BC147661; AAI47662.1; -; mRNA.
DR CCDS; CCDS38262.1; -.
DR RefSeq; NP_001078990.1; NM_001085521.2.
DR RefSeq; XP_006499937.1; XM_006499874.3.
DR RefSeq; XP_011237987.1; XM_011239685.2.
DR RefSeq; XP_011237989.1; XM_011239687.2.
DR AlphaFoldDB; A2ANU3; -.
DR STRING; 10090.ENSMUSP00000105561; -.
DR iPTMnet; A2ANU3; -.
DR PhosphoSitePlus; A2ANU3; -.
DR SwissPalm; A2ANU3; -.
DR MaxQB; A2ANU3; -.
DR PaxDb; A2ANU3; -.
DR PeptideAtlas; A2ANU3; -.
DR PRIDE; A2ANU3; -.
DR ProteomicsDB; 254708; -.
DR ABCD; A2ANU3; 1 sequenced antibody.
DR Antibodypedia; 62829; 29 antibodies from 14 providers.
DR Ensembl; ENSMUST00000109934; ENSMUSP00000105560; ENSMUSG00000074736.
DR Ensembl; ENSMUST00000109935; ENSMUSP00000105561; ENSMUSG00000074736.
DR GeneID; 433485; -.
DR KEGG; mmu:433485; -.
DR UCSC; uc012cfp.1; mouse.
DR CTD; 79953; -.
DR MGI; MGI:3702158; Syndig1.
DR VEuPathDB; HostDB:ENSMUSG00000074736; -.
DR eggNOG; ENOG502QQXK; Eukaryota.
DR GeneTree; ENSGT00950000183147; -.
DR HOGENOM; CLU_094250_0_0_1; -.
DR InParanoid; A2ANU3; -.
DR OMA; LGSECCE; -.
DR OrthoDB; 1273993at2759; -.
DR PhylomeDB; A2ANU3; -.
DR TreeFam; TF331357; -.
DR BioGRID-ORCS; 433485; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Syndig1; mouse.
DR PRO; PR:A2ANU3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2ANU3; protein.
DR Bgee; ENSMUSG00000074736; Expressed in cerebellum lobe and 97 other tissues.
DR ExpressionAtlas; A2ANU3; baseline and differential.
DR Genevisible; A2ANU3; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0044297; C:cell body; ISS:UniProtKB.
DR GO; GO:0043198; C:dendritic shaft; ISS:UniProtKB.
DR GO; GO:0043197; C:dendritic spine; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IDA:UniProtKB.
DR GO; GO:0060076; C:excitatory synapse; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IDA:UniProtKB.
DR GO; GO:0098839; C:postsynaptic density membrane; IDA:MGI.
DR GO; GO:0030672; C:synaptic vesicle membrane; IDA:MGI.
DR GO; GO:0035254; F:glutamate receptor binding; IPI:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IDA:UniProtKB.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:UniProtKB.
DR GO; GO:0097091; P:synaptic vesicle clustering; ISS:UniProtKB.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Endosome; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Reference proteome; Signal-anchor; Synapse;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..258
FT /note="Synapse differentiation-inducing gene protein 1"
FT /id="PRO_0000394033"
FT TOPO_DOM 1..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..228
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT INTRAMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q58DZ9"
SQ SEQUENCE 258 AA; 28456 MW; 90580C01DD5C1267 CRC64;
MDGIIEQKSV LVHSKISDAG KRNGLINTRN FMAESRDGLV SVYPAPQYQS HRLVASAAPG
SLEGGRSEPV QQLLDPNTLQ QSVESHYRPN IILYSDGVLR SWGDGVATDC CETTFIEDRS
PTKDSLEYPD GKFIDLSGDD IKIHTLSYDV EEEEELQELE SDYSSDTESE DNFLMMPPRD
HLGLSVFSML CCFWPLGIAA FYLSHETNKA VAKGDFHQAS TSSRRALFLA VLSITIGTGI
YVGVAVALIA YLSKNNHL
