SYNPR_HUMAN
ID SYNPR_HUMAN Reviewed; 265 AA.
AC Q8TBG9; B2R675; G5E9W4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Synaptoporin;
GN Name=SYNPR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Mao Y., Xie Y., Cheng C.;
RT "Cloning and characterization of a novel human synaptophysin-like
RT protein.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Intrinsic membrane protein of small synaptic vesicles.
CC Probable vesicular channel protein (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8TBG9; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-10273251, EBI-12003442;
CC Q8TBG9; Q9UPQ8: DOLK; NbExp=3; IntAct=EBI-10273251, EBI-8645574;
CC Q8TBG9; Q969F0: FATE1; NbExp=3; IntAct=EBI-10273251, EBI-743099;
CC Q8TBG9; Q8N3T1: GALNT15; NbExp=3; IntAct=EBI-10273251, EBI-3925203;
CC Q8TBG9; O60883: GPR37L1; NbExp=3; IntAct=EBI-10273251, EBI-2927498;
CC Q8TBG9; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-10273251, EBI-12007212;
CC Q8TBG9; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-10273251, EBI-11721828;
CC Q8TBG9; P43005: SLC1A1; NbExp=3; IntAct=EBI-10273251, EBI-745376;
CC Q8TBG9; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-10273251, EBI-8640191;
CC Q8TBG9; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-10273251, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TBG9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TBG9-2; Sequence=VSP_046199;
CC -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC {ECO:0000305}.
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DR EMBL; AF411860; AAN03681.2; -; mRNA.
DR EMBL; AK312465; BAG35372.1; -; mRNA.
DR EMBL; AL834457; CAD39117.1; -; mRNA.
DR EMBL; CR936762; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC099056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW65413.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW65414.1; -; Genomic_DNA.
DR EMBL; BC022518; AAH22518.1; -; mRNA.
DR CCDS; CCDS46859.1; -. [Q8TBG9-2]
DR CCDS; CCDS46860.1; -. [Q8TBG9-1]
DR RefSeq; NP_001123475.1; NM_001130003.1. [Q8TBG9-2]
DR RefSeq; NP_653243.1; NM_144642.4. [Q8TBG9-1]
DR AlphaFoldDB; Q8TBG9; -.
DR BioGRID; 126311; 14.
DR IntAct; Q8TBG9; 12.
DR STRING; 9606.ENSP00000418994; -.
DR GlyGen; Q8TBG9; 2 sites.
DR iPTMnet; Q8TBG9; -.
DR PhosphoSitePlus; Q8TBG9; -.
DR BioMuta; SYNPR; -.
DR DMDM; 48474879; -.
DR MassIVE; Q8TBG9; -.
DR PaxDb; Q8TBG9; -.
DR PeptideAtlas; Q8TBG9; -.
DR PRIDE; Q8TBG9; -.
DR ProteomicsDB; 34063; -.
DR ProteomicsDB; 74016; -. [Q8TBG9-1]
DR Antibodypedia; 31743; 168 antibodies from 23 providers.
DR DNASU; 132204; -.
DR Ensembl; ENST00000295894.9; ENSP00000295894.5; ENSG00000163630.11. [Q8TBG9-1]
DR Ensembl; ENST00000478300.6; ENSP00000418994.1; ENSG00000163630.11. [Q8TBG9-2]
DR GeneID; 132204; -.
DR KEGG; hsa:132204; -.
DR MANE-Select; ENST00000478300.6; ENSP00000418994.1; NM_001130003.2; NP_001123475.1. [Q8TBG9-2]
DR UCSC; uc003dlp.4; human. [Q8TBG9-1]
DR CTD; 132204; -.
DR DisGeNET; 132204; -.
DR GeneCards; SYNPR; -.
DR HGNC; HGNC:16507; SYNPR.
DR HPA; ENSG00000163630; Group enriched (brain, retina).
DR neXtProt; NX_Q8TBG9; -.
DR OpenTargets; ENSG00000163630; -.
DR PharmGKB; PA38154; -.
DR VEuPathDB; HostDB:ENSG00000163630; -.
DR eggNOG; ENOG502QT4W; Eukaryota.
DR GeneTree; ENSGT01030000234637; -.
DR HOGENOM; CLU_064642_0_1_1; -.
DR InParanoid; Q8TBG9; -.
DR OMA; NHGGYNQ; -.
DR OrthoDB; 1446480at2759; -.
DR PhylomeDB; Q8TBG9; -.
DR TreeFam; TF315804; -.
DR PathwayCommons; Q8TBG9; -.
DR SignaLink; Q8TBG9; -.
DR BioGRID-ORCS; 132204; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; SYNPR; human.
DR GeneWiki; SYNPR; -.
DR GenomeRNAi; 132204; -.
DR Pharos; Q8TBG9; Tbio.
DR PRO; PR:Q8TBG9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8TBG9; protein.
DR Bgee; ENSG00000163630; Expressed in lateral nuclear group of thalamus and 117 other tissues.
DR ExpressionAtlas; Q8TBG9; baseline and differential.
DR Genevisible; Q8TBG9; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR001285; Synaptophysin/porin.
DR PANTHER; PTHR10306; PTHR10306; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR00220; SYNAPTOPHYSN.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS00604; SYNAPTOP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasmic vesicle; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..265
FT /note="Synaptoporin"
FT /id="PRO_0000179157"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..81
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..177
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..202
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REPEAT 210..214
FT /note="1"
FT REPEAT 222..226
FT /note="2"
FT REPEAT 227..231
FT /note="3"
FT REPEAT 232..236
FT /note="4"
FT REPEAT 238..242
FT /note="5"
FT REGION 210..242
FT /note="5 X approximate repeats"
FT REGION 221..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22831"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..8
FT /note="MCMVIFAP -> MDPVSQLASAGTFRVLKEPLAFLRALEL (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_046199"
SQ SEQUENCE 265 AA; 29166 MW; 2A9DEC870A70F947 CRC64;
MCMVIFAPLF AIFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR LHQVTFEVPT
CEGKERQKLA LIGDSSSSAE FFVTVAVFAF LYSLAATVVY IFFQNKYREN NRGPLIDFIV
TVVFSFLWLV GSSAWAKGLS DVKVATDPKE VLLLMSACKQ PSNKCMAIHS PVMSSLNTSV
VFGFLNFILW AGNIWFVFKE TGWHSSGQRY LSDPMEKHSS SYNQGGYNQD SYGSSSGYSQ
QASLGPTSDE FGQQPTGPTS FTNQI
