SYNPR_RAT
ID SYNPR_RAT Reviewed; 265 AA.
AC P22831; Q9ERH1;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Synaptoporin;
GN Name=Synpr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=2206533; DOI=10.1016/0896-6273(90)90084-s;
RA Knaus P., Marqueze-Pouey B., Scherer H., Betz H.;
RT "Synaptoporin, a novel putative channel protein of synaptic vesicles.";
RL Neuron 5:453-462(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Spinal ganglion;
RA Xiao H., Huang Q., Zhang F., Yang Z., Chen Z., Han Z., Zhang X.;
RT "Novel genes expressed in rat dorsal root ganglion.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Intrinsic membrane protein of small synaptic vesicles.
CC Probable vesicular channel protein.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane; Multi-pass membrane protein. Synapse, synaptosome.
CC -!- TISSUE SPECIFICITY: Central nervous system.
CC -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC {ECO:0000305}.
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DR EMBL; AF306459; AAG33231.1; -; mRNA.
DR PIR; JH0300; JH0300.
DR RefSeq; NP_076464.1; NM_023974.1.
DR AlphaFoldDB; P22831; -.
DR STRING; 10116.ENSRNOP00000011307; -.
DR GlyGen; P22831; 3 sites.
DR iPTMnet; P22831; -.
DR PhosphoSitePlus; P22831; -.
DR PaxDb; P22831; -.
DR PRIDE; P22831; -.
DR Ensembl; ENSRNOT00000011307; ENSRNOP00000011307; ENSRNOG00000008203.
DR GeneID; 66030; -.
DR KEGG; rno:66030; -.
DR CTD; 132204; -.
DR RGD; 708366; Synpr.
DR eggNOG; ENOG502QT4W; Eukaryota.
DR GeneTree; ENSGT01030000234637; -.
DR InParanoid; P22831; -.
DR OMA; NHGGYNQ; -.
DR OrthoDB; 1446480at2759; -.
DR PhylomeDB; P22831; -.
DR TreeFam; TF315804; -.
DR PRO; PR:P22831; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000008203; Expressed in frontal cortex and 15 other tissues.
DR ExpressionAtlas; P22831; baseline and differential.
DR Genevisible; P22831; RN.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030285; C:integral component of synaptic vesicle membrane; IDA:SynGO.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR001285; Synaptophysin/porin.
DR PANTHER; PTHR10306; PTHR10306; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR00220; SYNAPTOPHYSN.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS00604; SYNAPTOP; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Synapse; Synaptosome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..265
FT /note="Synaptoporin"
FT /id="PRO_0000179159"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..81
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..177
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..202
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REPEAT 210..214
FT /note="1"
FT REPEAT 222..226
FT /note="2"
FT REPEAT 227..231
FT /note="3"
FT REPEAT 232..236
FT /note="4"
FT REPEAT 238..242
FT /note="5"
FT REGION 210..242
FT /note="5 X approximate repeats"
FT REGION 221..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 220
FT /note="Phosphoserine"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 68..69
FT /note="KL -> NV (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 167
FT /note="A -> G (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 29107 MW; F121BD8B79F71A28 CRC64;
MCMVIFAPLF AIFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR LHQVTFEVPT
CEGKERQKLA LVGDSSSSAE FFVTVAVFAF LYSLAATVVY IFFQNKYREN NRGPLIDFIV
TVVFSFLWLV GSSAWAKGLS DVKVATDPKE VLLLMSACKQ PSNKCMAVHS PVMSSLNTSV
VFGFLNFILW AGNIWFVFKE TGWHSSGQRY LSDPMEKHSS SYNQGGYNQD SYGSSGGYSQ
QASLGPTSDE FGQQPSGPTS FNNQI
