ID   BMI1B_XENLA             Reviewed;         323 AA.
AC   Q640D5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Polycomb complex protein BMI-1-B;
DE   AltName: Full=Polycomb group RING finger protein 4-B;
GN   Name=bmi1b; Synonyms=pcgf4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility.
CC       In the PRC1 complex, it is required to stimulate the E3 ubiquitin-
CC       protein ligase activity of rnf2 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a PRC1-like complex. Interacts with cbx4 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC082694; AAH82694.1; -; mRNA.
DR   RefSeq; NP_001088007.1; NM_001094538.1.
DR   AlphaFoldDB; Q640D5; -.
DR   SMR; Q640D5; -.
DR   DNASU; 494698; -.
DR   GeneID; 494698; -.
DR   KEGG; xla:494698; -.
DR   CTD; 494698; -.
DR   Xenbase; XB-GENE-942193; bmi1.L.
DR   OrthoDB; 1344247at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 494698; Expressed in brain and 19 other tissues.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; ISS:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..323
FT                   /note="Polycomb complex protein BMI-1-B"
FT                   /id="PRO_0000296633"
FT   ZN_FING         18..57
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          238..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           81..95
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        240..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..310
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  36573 MW;  B046BD17A43123B4 CRC64;
     MHRTTRIKIT ELNPHLMCVL CGGYFIDAAT IIECLHSFCK TCIVRYLETS KYCPICDVQV
     HKTRPLLNIR ADKTLQDIVY KLVPGLFKGE MKRRRDFYAA HPSVDAANGS NEDRGEVADE
     DKRIITDDEI ISLSIEFFDQ NRANRKGSKD KEKSKDEAND KRYLRCPAAL TIMHLRKFLR
     SKMDIPSNFQ IDVMYEEEPL KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRVKINPHT
     DRINNTSGDM ESDSGSDKAG SLGGGIPSTS SCMPRPPVQS PHPHFPHISS TINGTNSSSS
     HQNPFANRAR KISLNGVSAI SSG