ID   SYO1_YEAST              Reviewed;         620 AA.
AC   Q07395; D6VRT4; P89893; Q7LGT0;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Synchronized import protein 1;
DE   AltName: Full=Symportin 1;
GN   Name=SYO1; OrderedLocusNames=YDL063C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   INTERACTION WITH RPL5; RPL11A AND RPL11B, SUBCELLULAR LOCATION, AND
RP   FUNCTION.
RX   PubMed=23118189; DOI=10.1126/science.1226960;
RA   Kressler D., Bange G., Ogawa Y., Stjepanovic G., Bradatsch B., Pratte D.,
RA   Amlacher S., Strauss D., Yoneda Y., Katahira J., Sinning I., Hurt E.;
RT   "Synchronizing nuclear import of ribosomal proteins with ribosome
RT   assembly.";
RL   Science 338:666-671(2012).
CC   -!- FUNCTION: Nuclear import adapter that specifically recruits the two
CC       functionally and topologically linked ribosomal proteins RPL5 and RPL11
CC       (encoded by RPL11A and RPL11B). Guarantees that this cargo pair remains
CC       bound together from the time of synthesis in the cytoplasm until
CC       delivery to the nascent 5S rRNA in the nucleus.
CC       {ECO:0000269|PubMed:23118189}.
CC   -!- SUBUNIT: Forms a heterotrimeric complex with RPL5 and RPL11A or RPL11B.
CC       Interaction of this complex with KAP104 allows the nuclear import of
CC       the heterotrimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The SYO1/RPL11/RPL5
CC       complex is transported into the nucleus by KAP104.
CC   -!- MISCELLANEOUS: Present with 2600 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z74111; CAA98627.1; -; Genomic_DNA.
DR   EMBL; Z74109; CAA98625.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11794.1; -; Genomic_DNA.
DR   PIR; S67598; S67598.
DR   RefSeq; NP_010220.1; NM_001180122.1.
DR   AlphaFoldDB; Q07395; -.
DR   SMR; Q07395; -.
DR   BioGRID; 31996; 69.
DR   DIP; DIP-1789N; -.
DR   IntAct; Q07395; 3.
DR   MINT; Q07395; -.
DR   STRING; 4932.YDL063C; -.
DR   iPTMnet; Q07395; -.
DR   MaxQB; Q07395; -.
DR   PaxDb; Q07395; -.
DR   PRIDE; Q07395; -.
DR   EnsemblFungi; YDL063C_mRNA; YDL063C; YDL063C.
DR   GeneID; 851497; -.
DR   KEGG; sce:YDL063C; -.
DR   SGD; S000002221; SYO1.
DR   VEuPathDB; FungiDB:YDL063C; -.
DR   eggNOG; ENOG502RYAI; Eukaryota.
DR   GeneTree; ENSGT00390000012529; -.
DR   HOGENOM; CLU_446315_0_0_1; -.
DR   InParanoid; Q07395; -.
DR   OMA; ARDPAPI; -.
DR   BioCyc; YEAST:G3O-29478-MON; -.
DR   PRO; PR:Q07395; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q07395; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0051082; F:unfolded protein binding; IDA:SGD.
DR   GO; GO:0006606; P:protein import into nucleus; IGI:SGD.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IMP:SGD.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..620
FT                   /note="Synchronized import protein 1"
FT                   /id="PRO_0000248459"
FT   REPEAT          25..64
FT                   /note="ARM 1"
FT   REPEAT          66..106
FT                   /note="ARM 2"
FT   REPEAT          181..221
FT                   /note="ARM 3"
FT   REPEAT          258..299
FT                   /note="ARM 4"
FT   REPEAT          340..386
FT                   /note="ARM 5"
FT   REPEAT          435..470
FT                   /note="ARM 6"
FT   REPEAT          471..510
FT                   /note="ARM 7"
FT   REPEAT          564..607
FT                   /note="ARM 8"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  70164 MW;  54BDA2DFD47B1CF8 CRC64;
     MGRSKKRSRA SSSRLNPLRK AGSNDNNKDT NVVNKKLQPL LQNLSSVVPN DRSIALSSIS
     VLCEDAHMRQ LLLKEKLVPI ILNKLLNDSN SDIVVESFGL LRNLSLEEGY DVSIYLWRSD
     IWTSITSNFG RIVESLSALQ AAEQQPQLKP AGKSKIESKR LLFDFADNLL SLVVALSNGS
     DDILNEILTE SKINEIFQVI SQLLKYGVEK LPINLFNTTL DLIYDLSSES FEFIDHVSNN
     ELLSQFLNGL SPALHPQANE LTKVLIEGIH CQFLDMKITY DQCNKMIHSV CHSINNIDPV
     QLVNDINNPV EIGPATSKDE SSKVITKIKD YNAKRNESMI KLQSIEIAID LITAIIEIVA
     SKYESPESQE VAIPEELINT LTNFLPHVFM ILKDTFTSRI LIGWNNLIWL FVSLSLTELS
     GELLTTLWSY VTQLDSQDDL SIKIGRMGCI WALLKLIFPD GAFESENRAL INVQMLNNSG
     FARGIIEEFQ NNNDLELQQK CINVLSTYAM IQGQIDANKE IGQFFIQTLT QLNVRPEILI
     EMTNSLFQIY GDASYDYNEP IFVRGGFLSI LKDQVVPNLR QQFKMVDKNK NPELKERCHD
     CFTTLDSFIH YKMNENSTNQ