SYP2L_HUMAN
ID SYP2L_HUMAN Reviewed; 977 AA.
AC Q9H987; A5PKV9; Q68A20;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Synaptopodin 2-like protein;
GN Name=SYNPO2L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Heart;
RA Sugiyama A., Inoue H., Oka M.;
RT "Homo sapiens cDNA.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Actin-associated protein that may play a role in modulating
CC actin-based shape. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H987-2; P12814: ACTN1; NbExp=3; IntAct=EBI-12082116, EBI-351710;
CC Q9H987-2; P35609: ACTN2; NbExp=3; IntAct=EBI-12082116, EBI-77797;
CC Q9H987-2; Q08043: ACTN3; NbExp=3; IntAct=EBI-12082116, EBI-2880652;
CC Q9H987-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-12082116, EBI-618309;
CC Q9H987-2; P28070: PSMB4; NbExp=3; IntAct=EBI-12082116, EBI-603350;
CC Q9H987-2; O60504: SORBS3; NbExp=3; IntAct=EBI-12082116, EBI-741237;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H987-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H987-2; Sequence=VSP_011495, VSP_011496;
CC -!- SIMILARITY: Belongs to the synaptopodin family. {ECO:0000305}.
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DR EMBL; AB188489; BAD37139.1; -; mRNA.
DR EMBL; AK022983; BAB14346.1; -; mRNA.
DR EMBL; AC073389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471083; EAW54507.1; -; Genomic_DNA.
DR EMBL; BC142635; AAI42636.1; -; mRNA.
DR CCDS; CCDS44438.1; -. [Q9H987-1]
DR CCDS; CCDS7331.1; -. [Q9H987-2]
DR RefSeq; NP_001107605.1; NM_001114133.2. [Q9H987-1]
DR RefSeq; NP_079151.2; NM_024875.4. [Q9H987-2]
DR AlphaFoldDB; Q9H987; -.
DR SMR; Q9H987; -.
DR BioGRID; 123008; 29.
DR IntAct; Q9H987; 9.
DR MINT; Q9H987; -.
DR STRING; 9606.ENSP00000378289; -.
DR GlyGen; Q9H987; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H987; -.
DR PhosphoSitePlus; Q9H987; -.
DR BioMuta; SYNPO2L; -.
DR DMDM; 212276492; -.
DR EPD; Q9H987; -.
DR MassIVE; Q9H987; -.
DR MaxQB; Q9H987; -.
DR PaxDb; Q9H987; -.
DR PeptideAtlas; Q9H987; -.
DR PRIDE; Q9H987; -.
DR ProteomicsDB; 81295; -. [Q9H987-1]
DR ProteomicsDB; 81296; -. [Q9H987-2]
DR Antibodypedia; 45402; 74 antibodies from 22 providers.
DR DNASU; 79933; -.
DR Ensembl; ENST00000372873.8; ENSP00000361964.4; ENSG00000166317.12. [Q9H987-2]
DR Ensembl; ENST00000394810.3; ENSP00000378289.2; ENSG00000166317.12. [Q9H987-1]
DR GeneID; 79933; -.
DR KEGG; hsa:79933; -.
DR MANE-Select; ENST00000394810.3; ENSP00000378289.2; NM_001114133.3; NP_001107605.1.
DR UCSC; uc001jus.6; human. [Q9H987-1]
DR CTD; 79933; -.
DR DisGeNET; 79933; -.
DR GeneCards; SYNPO2L; -.
DR HGNC; HGNC:23532; SYNPO2L.
DR HPA; ENSG00000166317; Group enriched (heart muscle, skeletal muscle, tongue).
DR neXtProt; NX_Q9H987; -.
DR OpenTargets; ENSG00000166317; -.
DR PharmGKB; PA134889033; -.
DR VEuPathDB; HostDB:ENSG00000166317; -.
DR eggNOG; KOG1703; Eukaryota.
DR GeneTree; ENSGT00950000183054; -.
DR HOGENOM; CLU_007120_1_0_1; -.
DR InParanoid; Q9H987; -.
DR OMA; NRMDRYI; -.
DR OrthoDB; 109454at2759; -.
DR PhylomeDB; Q9H987; -.
DR TreeFam; TF330867; -.
DR PathwayCommons; Q9H987; -.
DR SignaLink; Q9H987; -.
DR BioGRID-ORCS; 79933; 56 hits in 1063 CRISPR screens.
DR ChiTaRS; SYNPO2L; human.
DR GenomeRNAi; 79933; -.
DR Pharos; Q9H987; Tbio.
DR PRO; PR:Q9H987; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9H987; protein.
DR Bgee; ENSG00000166317; Expressed in skeletal muscle tissue of rectus abdominis and 128 other tissues.
DR ExpressionAtlas; Q9H987; baseline and differential.
DR Genevisible; Q9H987; HS.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0030054; C:cell junction; IDA:HPA.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; ISS:BHF-UCL.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; ISS:BHF-UCL.
DR GO; GO:0032233; P:positive regulation of actin filament bundle assembly; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:BHF-UCL.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; ISS:BHF-UCL.
DR GO; GO:0045214; P:sarcomere organization; ISS:BHF-UCL.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton; Methylation;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..977
FT /note="Synaptopodin 2-like protein"
FT /id="PRO_0000187675"
FT DOMAIN 6..88
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 91..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..127
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..456
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..572
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..730
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..802
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 108
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 111
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 141
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 178
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 345
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 374
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 386
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 466
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 469
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 479
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 670
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 678
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 705
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 713
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 757
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 788
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 790
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 792
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 806
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 826
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 889
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 891
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 892
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 898
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 910
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 921
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 921
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 955
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT MOD_RES 957
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWB1"
FT VAR_SEQ 1..224
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_011495"
FT VAR_SEQ 225..258
FT /note="LRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAK -> METFEPISQEPLSQ
FT ASYDKAPDPVPELQDSFYAE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_011496"
FT VARIANT 508
FT /note="P -> H (in dbSNP:rs57006992)"
FT /id="VAR_061835"
FT VARIANT 707
FT /note="P -> L (in dbSNP:rs3812629)"
FT /id="VAR_019671"
FT VARIANT 833
FT /note="S -> Y (in dbSNP:rs34163229)"
FT /id="VAR_047065"
FT CONFLICT 748
FT /note="I -> T (in Ref. 2; BAB14346)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 977 AA; 102481 MW; 885B28CEE3C5B3D7 CRC64;
MGAEEEVLVT LSGGAPWGFR LHGGAEQRKP LQVSKIRRRS QAGRAGLRER DQLLAINGVS
CTNLSHASAM SLIDASGNQL VLTVQRLADE GPVQSPSPHE LQVLSPLSPL SPEPPGAPVP
QPLQPGSLRS PPDSEAYYGE TDSDADGPAT QEKPRRPRRR GPTRPTPPGA PPDEVYLSDS
PAEPAPTIPG PPSQGDSRVS SPSWEDGAAL QPPPAEALLL PHGPLRPGPH LIPMVGPVPH
PVAEDLTTTY TQKAKQAKLQ RAESLQEKSI KEAKTKCRTI ASLLTAAPNP HSKGVLMFKK
RRQRAKKYTL VSFGAAAGTG AEEEDGVPPT SESELDEEAF SDARSLTNQS DWDSPYLDME
LARAGSRASE GQGSGLGGQL SEVSGRGVQL FEQQRQRADS STQELARVEP AAMLNGEGLQ
SPPRAQSAPP EAAVLPPSPL PAPVASPRPF QPGGGAPTPA PSIFNRSARP FTPGLQGQRP
TTTSVIFRPL APKRANDSLG GLSPAPPPFL SSQGPTPLPS FTSGVPSHAP VSGSPSTPRS
SGPVTATSSL YIPAPSRPVT PGGAPEPPAP PSAAAMTSTA SIFLSAPLRP SARPEAPAPG
PGAPEPPSAR EQRISVPAAR TGILQEARRR GTRKQMFRPG KEETKNSPNP ELLSLVQNLD
EKPRAGGAES GPEEDALSLG AEACNFMQPV GARSYKTLPH VTPKTPPPMA PKTPPPMTPK
TPPPVAPKPP SRGLLDGLVN GAASSAGIPE PPRLQGRGGE LFAKRQSRAD RYVVEGTPGP
GLGPRPRSPS PTPSLPPSWK YSPNIRAPPP IAYNPLLSPF FPQAARTLPK AQSQGPRATP
KQGIKALDFM RHQPYQLKTA MFCFDEVPPT PGPIASGSPK TARVQEIRRF STPAPQPTAE
PLAPTVLAPR AATTLDEPIW RTELASAPVP SPAPPPEAPR GLGASPSSCG FQVARPRFSA
TRTGLQAHVW RPGAGHQ
