SYPL2_HUMAN
ID SYPL2_HUMAN Reviewed; 272 AA.
AC Q5VXT5; A8K0E8; A8KAL7; I0IT67; Q6ZMX1;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Synaptophysin-like protein 2;
GN Name=SYPL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=22290180; DOI=10.1016/j.brainres.2011.12.062;
RA Satoh K., Akatsu H., Yamamoto T., Kosaka K., Yokota H., Yamada T.;
RT "Mitsugumin 29 is transcriptionally induced in senile plaque-associated
RT astrocytes.";
RL Brain Res. 1441:9-16(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, Testis, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in communication between the T-tubular and
CC junctional sarcoplasmic reticulum (SR) membranes. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5VXT5-2; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-18196631, EBI-12069500;
CC Q5VXT5-2; O43681: GET3; NbExp=3; IntAct=EBI-18196631, EBI-2515857;
CC Q5VXT5-2; Q9Y342: PLLP; NbExp=3; IntAct=EBI-18196631, EBI-3919291;
CC Q5VXT5-2; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-18196631, EBI-10314552;
CC Q5VXT5-2; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-18196631, EBI-12266234;
CC Q5VXT5-2; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-18196631, EBI-751204;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=Triad junction, the junctional complex
CC between the transverse tubule and the sarcoplasmic reticulum.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VXT5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VXT5-2; Sequence=VSP_014268;
CC -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC {ECO:0000305}.
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DR EMBL; AB158472; BAM08466.1; -; mRNA.
DR EMBL; AK131459; BAD18604.1; -; mRNA.
DR EMBL; AK289513; BAF82202.1; -; mRNA.
DR EMBL; AK293082; BAF85771.1; -; mRNA.
DR EMBL; AL355145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471122; EAW56384.1; -; Genomic_DNA.
DR CCDS; CCDS41365.1; -. [Q5VXT5-1]
DR RefSeq; NP_001035799.1; NM_001040709.1. [Q5VXT5-1]
DR AlphaFoldDB; Q5VXT5; -.
DR BioGRID; 129915; 21.
DR IntAct; Q5VXT5; 19.
DR MINT; Q5VXT5; -.
DR STRING; 9606.ENSP00000358888; -.
DR GlyGen; Q5VXT5; 1 site.
DR PhosphoSitePlus; Q5VXT5; -.
DR BioMuta; SYPL2; -.
DR DMDM; 68566071; -.
DR jPOST; Q5VXT5; -.
DR MassIVE; Q5VXT5; -.
DR MaxQB; Q5VXT5; -.
DR PaxDb; Q5VXT5; -.
DR PeptideAtlas; Q5VXT5; -.
DR PRIDE; Q5VXT5; -.
DR ProteomicsDB; 65608; -. [Q5VXT5-1]
DR ProteomicsDB; 65609; -. [Q5VXT5-2]
DR Antibodypedia; 33759; 38 antibodies from 19 providers.
DR DNASU; 284612; -.
DR Ensembl; ENST00000369872.4; ENSP00000358888.3; ENSG00000143028.9. [Q5VXT5-1]
DR GeneID; 284612; -.
DR KEGG; hsa:284612; -.
DR MANE-Select; ENST00000369872.4; ENSP00000358888.3; NM_001040709.2; NP_001035799.1.
DR UCSC; uc001dxp.4; human. [Q5VXT5-1]
DR CTD; 284612; -.
DR DisGeNET; 284612; -.
DR GeneCards; SYPL2; -.
DR HGNC; HGNC:27638; SYPL2.
DR HPA; ENSG00000143028; Group enriched (skeletal muscle, tongue).
DR neXtProt; NX_Q5VXT5; -.
DR OpenTargets; ENSG00000143028; -.
DR PharmGKB; PA142670846; -.
DR VEuPathDB; HostDB:ENSG00000143028; -.
DR eggNOG; ENOG502RR69; Eukaryota.
DR GeneTree; ENSGT01030000234637; -.
DR HOGENOM; CLU_064642_1_1_1; -.
DR InParanoid; Q5VXT5; -.
DR OMA; YTMAALI; -.
DR OrthoDB; 1446480at2759; -.
DR PhylomeDB; Q5VXT5; -.
DR TreeFam; TF315804; -.
DR PathwayCommons; Q5VXT5; -.
DR SignaLink; Q5VXT5; -.
DR BioGRID-ORCS; 284612; 23 hits in 1065 CRISPR screens.
DR ChiTaRS; SYPL2; human.
DR GenomeRNAi; 284612; -.
DR Pharos; Q5VXT5; Tdark.
DR PRO; PR:Q5VXT5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VXT5; protein.
DR Bgee; ENSG00000143028; Expressed in tibialis anterior and 104 other tissues.
DR Genevisible; Q5VXT5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0021762; P:substantia nigra development; HEP:UniProtKB.
DR GO; GO:0033292; P:T-tubule organization; IEA:Ensembl.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR001285; Synaptophysin/porin.
DR PANTHER; PTHR10306; PTHR10306; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR00220; SYNAPTOPHYSN.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..272
FT /note="Synaptophysin-like protein 2"
FT /id="PRO_0000179166"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..116
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..213
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..238
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 240..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 217..272
FT /note="LFGFINFFLWAGNCWFVFKETPWHGQGQGQDQDQDQDQGQGPSQESAAEQGA
FT VEKQ -> VRPVATAGSSTSPAAQACPS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_014268"
FT CONFLICT 99
FT /note="E -> G (in Ref. 2; BAD18604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 272 AA; 30156 MW; 0A5998BA30B35A75 CRC64;
MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET
GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES SSKTMHLMGD FSAPAEFFVT
LGIFSFFYTM AALVIYLRFH NLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG
ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH
GQGQGQDQDQ DQDQGQGPSQ ESAAEQGAVE KQ
