SYPL2_MOUSE
ID SYPL2_MOUSE Reviewed; 264 AA.
AC O89104;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Synaptophysin-like protein 2;
DE AltName: Full=Mitsugumin-29;
DE Short=Mg29;
GN Name=Sypl2; Synonyms=Mg29;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129, and C57BL/6J;
RX PubMed=9708916; DOI=10.1016/s0014-5793(98)00770-4;
RA Shimuta M., Komazaki S., Nishi M., Iino M., Nakagawara K., Takeshima H.;
RT "Structure and expression of mitsugumin29 gene.";
RL FEBS Lett. 431:263-267(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in communication between the T-tubular and
CC junctional sarcoplasmic reticulum (SR) membranes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Triad
CC junction, the junctional complex between the transverse tubule and the
CC sarcoplasmic reticulum.
CC -!- TISSUE SPECIFICITY: Expressed abundantly in skeletal muscle and at
CC lower levels in the kidney. {ECO:0000269|PubMed:9708916}.
CC -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC {ECO:0000305}.
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DR EMBL; AB010144; BAA32531.1; -; Genomic_DNA.
DR EMBL; AB010140; BAA32530.1; -; mRNA.
DR EMBL; BC030038; AAH30038.1; -; mRNA.
DR CCDS; CCDS57253.1; -.
DR RefSeq; NP_032622.1; NM_008596.1.
DR AlphaFoldDB; O89104; -.
DR STRING; 10090.ENSMUSP00000116756; -.
DR GlyGen; O89104; 1 site.
DR iPTMnet; O89104; -.
DR PhosphoSitePlus; O89104; -.
DR jPOST; O89104; -.
DR MaxQB; O89104; -.
DR PaxDb; O89104; -.
DR PRIDE; O89104; -.
DR ProteomicsDB; 254743; -.
DR Antibodypedia; 33759; 38 antibodies from 19 providers.
DR DNASU; 17306; -.
DR Ensembl; ENSMUST00000141387; ENSMUSP00000116756; ENSMUSG00000027887.
DR GeneID; 17306; -.
DR KEGG; mmu:17306; -.
DR UCSC; uc008qyn.1; mouse.
DR CTD; 284612; -.
DR MGI; MGI:1328311; Sypl2.
DR VEuPathDB; HostDB:ENSMUSG00000027887; -.
DR eggNOG; ENOG502RR69; Eukaryota.
DR GeneTree; ENSGT01030000234637; -.
DR HOGENOM; CLU_064642_1_1_1; -.
DR InParanoid; O89104; -.
DR OMA; YTMAALI; -.
DR OrthoDB; 1446480at2759; -.
DR BioGRID-ORCS; 17306; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Sypl2; mouse.
DR PRO; PR:O89104; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O89104; protein.
DR Bgee; ENSMUSG00000027887; Expressed in vastus lateralis and 66 other tissues.
DR Genevisible; O89104; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
DR GO; GO:0007507; P:heart development; IGI:MGI.
DR GO; GO:0033292; P:T-tubule organization; IGI:MGI.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR001285; Synaptophysin/porin.
DR PANTHER; PTHR10306; PTHR10306; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR00220; SYNAPTOPHYSN.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..264
FT /note="Synaptophysin-like protein 2"
FT /id="PRO_0000179167"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..116
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..213
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..238
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 242..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 264 AA; 29224 MW; 5CB8A169533B6704 CRC64;
MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET
GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS TSKTMNLMGD FSAPAEFFVT
LGIFSFFYTM AALVIYLRFH KLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG
ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH
GQGQDQGQGP SQESAAEQGA VEKQ
