ID   SYPL2_RABIT             Reviewed;         264 AA.
AC   O62646;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Synaptophysin-like protein 2;
DE   AltName: Full=Mitsugumin-29;
DE            Short=Mg29;
GN   Name=SYPL2; Synonyms=MG29;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skeletal muscle;
RX   PubMed=9512495; DOI=10.1042/bj3310317;
RA   Takeshima H., Shimuta M., Komazaki S., Ohmi K., Nishi M., Iino M.,
RA   Miyata A., Kangawa K.;
RT   "Mitsugumin29, a novel synaptophysin family member from the triad junction
RT   in skeletal muscle.";
RL   Biochem. J. 331:317-322(1998).
CC   -!- FUNCTION: Involved in communication between the T-tubular and
CC       junctional sarcoplasmic reticulum (SR) membranes.
CC       {ECO:0000269|PubMed:9512495}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:9512495}; Multi-pass
CC       membrane protein {ECO:0000269|PubMed:9512495}. Note=Triad junction, the
CC       junctional complex between the transverse tubule and the sarcoplasmic
CC       reticulum.
CC   -!- TISSUE SPECIFICITY: Skeletal muscle.
CC   -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC       {ECO:0000305}.
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DR   EMBL; AB004816; BAA25784.1; -; mRNA.
DR   RefSeq; NP_001075455.1; NM_001081986.1.
DR   AlphaFoldDB; O62646; -.
DR   STRING; 9986.ENSOCUP00000021121; -.
DR   GeneID; 100008596; -.
DR   KEGG; ocu:100008596; -.
DR   CTD; 284612; -.
DR   eggNOG; ENOG502RR69; Eukaryota.
DR   InParanoid; O62646; -.
DR   OrthoDB; 1446480at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:InterPro.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR001285; Synaptophysin/porin.
DR   PANTHER; PTHR10306; PTHR10306; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR00220; SYNAPTOPHYSN.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..264
FT                   /note="Synaptophysin-like protein 2"
FT                   /id="PRO_0000179168"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..116
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..213
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..238
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   REGION          242..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        213
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  29312 MW;  CE534B48BC060845 CRC64;
     MSSTESPSRA ADKSPRQQVD RLLEGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET
     GAMVRCNNEA KDVSSIIVLF GYPFRLHRIE YEMPLCDDDS SSKTMHLMGD FSAPAEFFVT
     LGIFSFFYTM AALVVYLRFH KLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG
     ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH
     GQGQDQGQGP SQESAAEQGA VEKQ