ID   SYPX_LEPSY              Reviewed;          25 AA.
AC   P85279;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Syphaxin;
OS   Leptodactylus syphax (Burgundy thin-toed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leptodactylinae;
OC   Leptodactylus.
OX   NCBI_TaxID=459512;
RN   [1]
RP   PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT ILE-25.
RC   TISSUE=Skin secretion;
RX   PubMed=17628627; DOI=10.1016/j.toxicon.2007.04.027;
RA   Dourado F.S., Leite J.R.S.A., Silva L.P., Melo J.A.T., Bloch C. Jr.,
RA   Schwartz E.F.;
RT   "Antimicrobial peptide from the skin secretion of the frog Leptodactylus
RT   syphax.";
RL   Toxicon 50:572-580(2007).
CC   -!- FUNCTION: Has hemolytic and antibacterial activity.
CC       {ECO:0000250|UniProtKB:P83951}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17628627}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17628627}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC       {ECO:0000269|PubMed:17628627}.
CC   -!- MASS SPECTROMETRY: Mass=2543.74; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17628627};
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DR   AlphaFoldDB; P85279; -.
DR   SMR; P85279; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012518; Antimicrobial15.
DR   Pfam; PF08110; Antimicrobial15; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Hemolysis; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Syphaxin"
FT                   /evidence="ECO:0000269|PubMed:17628627"
FT                   /id="PRO_0000302762"
FT   MOD_RES         25
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:17628627"
SQ   SEQUENCE   25 AA;  2545 MW;  7DC0EACE1A06139F CRC64;
     GVLDILKGAA KDLAGHVATK VINKI