ID   BMP15_BOVIN             Reviewed;         394 AA.
AC   Q6PX77;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Bone morphogenetic protein 15;
DE            Short=BMP-15;
DE   Flags: Precursor;
GN   Name=BMP15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15189828; DOI=10.1095/biolreprod.104.030288;
RA   Pennetier S., Uzbekova S., Perreau C., Papillier P., Mermillod P.,
RA   Dalbies-Tran R.;
RT   "Spatio-temporal expression of the germ cell marker genes MATER, ZAR1,
RT   GDF9, BMP15, and VASA in adult bovine tissues, oocytes, and preimplantation
RT   embryos.";
RL   Biol. Reprod. 71:1359-1366(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Liu Y.B., Qi Y., Wang F., Rong W.;
RT   "Cloning of the cattle BMP15 gene.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in follicular development. Seems to be an
CC       oocyte-specific growth/differentiation factor that stimulates
CC       folliculogenesis and granulosa cell (GC) growth (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer or heterodimer (Potential). But, in contrast to
CC       other members of this family, cannot be disulfide-linked (By
CC       similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; AY572412; AAS99651.1; -; mRNA.
DR   EMBL; DQ463368; ABE97096.1; -; mRNA.
DR   RefSeq; NP_001026922.1; NM_001031752.1.
DR   AlphaFoldDB; Q6PX77; -.
DR   SMR; Q6PX77; -.
DR   STRING; 9913.ENSBTAP00000056137; -.
DR   PaxDb; Q6PX77; -.
DR   PRIDE; Q6PX77; -.
DR   Ensembl; ENSBTAT00000064918; ENSBTAP00000056137; ENSBTAG00000045782.
DR   GeneID; 353351; -.
DR   KEGG; bta:353351; -.
DR   CTD; 9210; -.
DR   VEuPathDB; HostDB:ENSBTAG00000045782; -.
DR   VGNC; VGNC:26516; BMP15.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00940000160940; -.
DR   HOGENOM; CLU_055377_0_0_1; -.
DR   InParanoid; Q6PX77; -.
DR   OMA; VYRHQLH; -.
DR   OrthoDB; 724783at2759; -.
DR   TreeFam; TF316134; -.
DR   Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-BTA-8957275; Post-translational protein phosphorylation.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000045782; Expressed in oocyte and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0070698; F:type I activin receptor binding; IBA:GO_Central.
DR   GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR   GO; GO:0060016; P:granulosa cell development; IEA:InterPro.
DR   GO; GO:0001541; P:ovarian follicle development; IEA:InterPro.
DR   GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR015923; BMP-15.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; PTHR11848; 1.
DR   PANTHER; PTHR11848:SF22; PTHR11848:SF22; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..269
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000244399"
FT   CHAIN           270..394
FT                   /note="Bone morphogenetic protein 15"
FT                   /id="PRO_0000244400"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        238
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        293..359
FT                   /evidence="ECO:0000250"
FT   DISULFID        322..391
FT                   /evidence="ECO:0000250"
FT   DISULFID        326..393
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   394 AA;  45025 MW;  27B560E210ECF034 CRC64;
     MVLLSILRIL LLWGLVLFME HRVQMTQVGQ PSIAHLPEAP TLPLIQELLE EAPGKQQRKP
     RILGHPLRYM LELYQRSADA SGHPRENRTI GATMVRLVRP LASVARPLRG SWHIQTLDFP
     LRPNRVAYQL VRATVVYRHQ LHLTHSHLSC HVEPWVQKSP TNHFPSSGRG SSKPSLLPKA
     WTEMDIMEHV GQKLWNHKGR RVLRLRFVCQ QPRGSEVREF WWHGTSSLDT VFLLLYFNDT
     QSVQKTKPLP KGLKEFTEKD PSLLLRRARQ AGSIASEVPG PSREHDGPES NLCSLHPFQV
     SFQQLGWDHW IIAPHLYTPN YCKGVCPRVL HYGLNSPNHA IIQNLVNELV DQSVPQPSCV
     PYKYVPISIL LIEANGSILY KEYEGMIAQS CTCR