ID   BMP15_SHEEP             Reviewed;         393 AA.
AC   Q9MZE2;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Bone morphogenetic protein 15;
DE            Short=BMP-15;
DE   AltName: Full=Growth/differentiation factor 9B;
DE            Short=GDF-9B;
DE   Flags: Precursor;
GN   Name=BMP15; Synonyms=GDF9B;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10888873; DOI=10.1038/77033;
RA   Galloway S.M., McNatty K.P., Cambridge L.M., Laitinen M.P.E., Juengel J.L.,
RA   Jokiranta S., McLaren R.J., Luiro K., Dodds K.D., Montgomery G.W.,
RA   Beattie A.E., Davis G.H., Ritvos O.;
RT   "Mutations in an oocyte-derived growth factor gene (BMP15) cause increased
RT   ovulation rate and infertility in a dosage-sensitive manner.";
RL   Nat. Genet. 25:279-283(2000).
CC   -!- FUNCTION: May be involved in follicular development. Oocyte-specific
CC       growth/differentiation factor that stimulates folliculogenesis and
CC       granulosa cell (GC) growth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (By similarity). But, in contrast to other members
CC       of this family, cannot be disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; AF236079; AAF81688.1; -; Genomic_DNA.
DR   EMBL; AF236078; AAF81688.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001108239.1; NM_001114767.1.
DR   AlphaFoldDB; Q9MZE2; -.
DR   STRING; 9940.ENSOARP00000010055; -.
DR   GeneID; 100141303; -.
DR   KEGG; oas:100141303; -.
DR   CTD; 9210; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   OrthoDB; 724783at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0060016; P:granulosa cell development; IEA:InterPro.
DR   GO; GO:0001541; P:ovarian follicle development; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR015923; BMP-15.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; PTHR11848; 1.
DR   PANTHER; PTHR11848:SF22; PTHR11848:SF22; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..268
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000033896"
FT   CHAIN           269..393
FT                   /note="Bone morphogenetic protein 15"
FT                   /id="PRO_0000033897"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        237
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        374
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        292..358
FT                   /evidence="ECO:0000250"
FT   DISULFID        321..390
FT                   /evidence="ECO:0000250"
FT   DISULFID        325..392
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   393 AA;  44900 MW;  ECEE0EC710690773 CRC64;
     MVLLSILRIL LWGLVLFMEH RVQMTQVGQP SIAHLPEAPT LPLIQELLEE APGKQQRKPR
     VLGHPLRYML ELYQRSADAS GHPRENRTIG ATMVRLVRPL ASVARPLRGS WHIQTLDFPL
     RPNRVAYQLV RATVVYRHQL HLTHSHLSCH VEPWVQKSPT NHFPSSGRGS SKPSLLPKTW
     TEMDIMEHVG QKLWNHKGRR VLRLRFVCQQ PRGSEVLEFW WHGTSSLDTV FLLLYFNDTQ
     SVQKTKPLPK GLKEFTEKDP SLLLRRARQA GSIASEVPGP SREHDGPESN QCSLHPFQVS
     FQQLGWDHWI IAPHLYTPNY CKGVCPRVLH YGLNSPNHAI IQNLVSELVD QNVPQPSCVP
     YKYVPISILL IEANGSILYK EYEGMIAQSC TCR