BMP2_TETNG
ID BMP2_TETNG Reviewed; 420 AA.
AC Q804S2; Q4SCZ1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Bone morphogenetic protein 2;
DE Short=BMP-2;
DE Flags: Precursor;
GN Name=bmp2; ORFNames=GSTENG00020275001;
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Laize V., Pombinho A.R., Cancela M.L.;
RT "Identification of Tetraodon nigroviridis bone morphogenetic protein 2
RT (BMP-2) by comparative genomics.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
CC -!- FUNCTION: Induces cartilage and bone formation. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:P12643}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; AF542093; AAO33820.1; -; Genomic_DNA.
DR EMBL; CAAE01014646; CAG01491.1; -; Genomic_DNA.
DR AlphaFoldDB; Q804S2; -.
DR SMR; Q804S2; -.
DR STRING; 99883.ENSTNIP00000013645; -.
DR Ensembl; ENSTNIT00000013839; ENSTNIP00000013645; ENSTNIG00000010727.
DR KEGG; tng:GSTEN00020275G001; -.
DR GeneTree; ENSGT00940000155666; -.
DR HOGENOM; CLU_020515_4_2_1; -.
DR InParanoid; Q804S2; -.
DR OMA; WTSGKGH; -.
DR TreeFam; TF351789; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0048264; P:determination of ventral identity; IEA:Ensembl.
DR GO; GO:0060030; P:dorsal convergence; IEA:Ensembl.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0090008; P:hypoblast development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0021703; P:locus ceruleus development; IEA:Ensembl.
DR GO; GO:0001710; P:mesodermal cell fate commitment; IEA:Ensembl.
DR GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0022008; P:neurogenesis; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR GO; GO:0061131; P:pancreas field specification; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0060876; P:semicircular canal formation; IEA:Ensembl.
DR GO; GO:0055015; P:ventricular cardiac muscle cell development; IEA:Ensembl.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Growth factor; Osteogenesis; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..303
FT /evidence="ECO:0000250"
FT /id="PRO_0000042925"
FT CHAIN 304..420
FT /note="Bone morphogenetic protein 2"
FT /id="PRO_0000042926"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 320..385
FT /evidence="ECO:0000250"
FT DISULFID 349..417
FT /evidence="ECO:0000250"
FT DISULFID 353..419
FT /evidence="ECO:0000250"
FT DISULFID 384
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 254
FT /note="Q -> H (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="K -> N (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 290
FT /note="D -> N (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="E -> D (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="S -> F (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 378
FT /note="S -> L (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="C -> W (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="Y -> F (in Ref. 1; AAO33820)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 47625 MW; A72B05DDE6D3E6F7 CRC64;
MVAVVRSLMV LLLAQVLLEG ATGLIPEVGR RRYSESGKQS PQQSEGFLNE FELRLLNMFG
LKRRPTPSKQ AVVPQYMVDL YRMHSANGDH SAKRPKSMGR HAERAASKAN TIRSFHHEES
MEALARLKGK TTQQFYFNLT SIPKEELITS AELRIYRDQV MGAASTNNSS TNSSTSDKAH
AGGFHRINIY EIFGVPQGRE PLARLLDTRL VQDSLTRWES FDVSSAVFQW TSGKGHNHGF
MIEVLHPEEG EVEQERADKH SRHVRVSRSL HQDRDSWPQA RPLLVTYGHD GRGDSVLHTR
EKRQAALRKQ RRKHQHKASC KRHALYVDFS DVGWNEWIVA PPGYHAFYCQ GECPFPLADH
LNSTNHAIVQ TLVNSVNSNI PRACCVPTDL SPISLLYLDE YEKVILKNYQ DMVVEGCGCR
