ID   BMPA_LACLM              Reviewed;         351 AA.
AC   A2RK47;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=ABC transporter nucleoside-binding protein BmpA {ECO:0000305};
DE   Flags: Precursor;
GN   Name=bmpA {ECO:0000303|PubMed:20595258};
GN   OrderedLocusNames=llmg_1064 {ECO:0000312|EMBL:CAL97657.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   FUNCTION, SUBUNIT, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=MG1363;
RX   PubMed=20595258; DOI=10.1099/mic.0.039818-0;
RA   Martinussen J., Soerensen C., Jendresen C.B., Kilstrup M.;
RT   "Two nucleoside transporters in Lactococcus lactis with different substrate
RT   specificities.";
RL   Microbiology 156:3148-3157(2010).
CC   -!- FUNCTION: Part of an ABC transporter complex involved in the uptake of
CC       all common nucleosides. {ECO:0000269|PubMed:20595258}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NupA),
CC       two transmembrane proteins (NupB and NupC) and a solute-binding protein
CC       (BmpA). {ECO:0000305|PubMed:20595258}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- INDUCTION: Expression is induced in the presence of purine via PurR.
CC       {ECO:0000269|PubMed:20595258}.
CC   -!- DISRUPTION PHENOTYPE: Mutant is unable to grow on inosine as a sole
CC       purine source. {ECO:0000269|PubMed:20595258}.
CC   -!- SIMILARITY: Belongs to the BMP lipoprotein family. {ECO:0000305}.
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DR   EMBL; AM406671; CAL97657.1; -; Genomic_DNA.
DR   RefSeq; WP_011834979.1; NZ_WJVF01000031.1.
DR   AlphaFoldDB; A2RK47; -.
DR   SMR; A2RK47; -.
DR   STRING; 416870.llmg_1064; -.
DR   EnsemblBacteria; CAL97657; CAL97657; llmg_1064.
DR   KEGG; llm:llmg_1064; -.
DR   eggNOG; COG1744; Bacteria.
DR   HOGENOM; CLU_038813_0_0_9; -.
DR   OMA; LASMMKR; -.
DR   PhylomeDB; A2RK47; -.
DR   BioCyc; LLAC416870:LLMG_RS05400-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR003760; PnrA-like.
DR   Pfam; PF02608; Bmp; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..351
FT                   /note="ABC transporter nucleoside-binding protein BmpA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_5002645759"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   351 AA;  36861 MW;  1F2999513A7F0D35 CRC64;
     MKKRVIAVSA IALASVAVLA GCRSHDASGT SGKVKTDLKA AIVTDANGVN DRSFNQSAWE
     GLQSWGKENN LKKGTGYTYF QSNSASDYTT NYNSAEQQGY KLLFGIGFSL QDATSAAAKN
     NPKSNFVIVD SVIKDQKNVT SATFADNESA YLAGVAAAKA TKTNKIGFIG GMQSDVITRF
     EKGYVAGAKS VKSDIKVDIQ YAGSFSDAAK GKTIAAAMYG SGDDVVYQCA GGVGTGVFSE
     AKALNSSKNE ADKVWVIGVD QDQEYLGKYK SKDGKDSNFV LVSTIKEVGT VVKDIADKTK
     DGKFPGGTIV TYNLKNGGVD LGLDNATSEI KDAVAKAKTD IIDGKITVPS K