ABRAL_HUMAN
ID ABRAL_HUMAN Reviewed; 81 AA.
AC Q9P1F3; Q5SZC8; Q9P0A1;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Costars family protein ABRACL;
DE AltName: Full=ABRA C-terminal-like protein;
GN Name=ABRACL; Synonyms=C6orf115; ORFNames=HSPC280, PRO2013;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal liver;
RA Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J.,
RA Liu M., He F.;
RT "Functional prediction of the coding sequences of 121 new genes deduced by
RT analysis of cDNA clones from human fetal liver.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 1-16.
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R.,
RA Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass spectrometric
RT identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [9]
RP STRUCTURE BY NMR OF 1-81.
RX PubMed=21082705; DOI=10.1002/pro.548;
RA Lin J., Zhou T., Wang J.;
RT "Solution structure of the human HSPC280 protein.";
RL Protein Sci. 20:216-223(2011).
CC -!- SIMILARITY: Belongs to the costars family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF28958.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF116682; AAF71102.1; -; mRNA.
DR EMBL; AF161398; AAF28958.1; ALT_INIT; mRNA.
DR EMBL; AL590308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW47902.1; -; Genomic_DNA.
DR EMBL; BC014953; AAH14953.1; -; mRNA.
DR CCDS; CCDS43509.1; -.
DR RefSeq; NP_067066.1; NM_021243.2.
DR RefSeq; XP_016866640.1; XM_017011151.1.
DR PDB; 2L2O; NMR; -; A=1-81.
DR PDBsum; 2L2O; -.
DR AlphaFoldDB; Q9P1F3; -.
DR BMRB; Q9P1F3; -.
DR SMR; Q9P1F3; -.
DR BioGRID; 121847; 7.
DR IntAct; Q9P1F3; 4.
DR STRING; 9606.ENSP00000356632; -.
DR iPTMnet; Q9P1F3; -.
DR PhosphoSitePlus; Q9P1F3; -.
DR BioMuta; ABRACL; -.
DR EPD; Q9P1F3; -.
DR jPOST; Q9P1F3; -.
DR MassIVE; Q9P1F3; -.
DR MaxQB; Q9P1F3; -.
DR PaxDb; Q9P1F3; -.
DR PeptideAtlas; Q9P1F3; -.
DR PRIDE; Q9P1F3; -.
DR ProteomicsDB; 83647; -.
DR TopDownProteomics; Q9P1F3; -.
DR Antibodypedia; 33082; 65 antibodies from 14 providers.
DR DNASU; 58527; -.
DR Ensembl; ENST00000367660.4; ENSP00000356632.3; ENSG00000146386.8.
DR GeneID; 58527; -.
DR KEGG; hsa:58527; -.
DR MANE-Select; ENST00000367660.4; ENSP00000356632.3; NM_021243.3; NP_067066.1.
DR UCSC; uc003qil.2; human.
DR CTD; 58527; -.
DR DisGeNET; 58527; -.
DR GeneCards; ABRACL; -.
DR HGNC; HGNC:21230; ABRACL.
DR HPA; ENSG00000146386; Low tissue specificity.
DR neXtProt; NX_Q9P1F3; -.
DR OpenTargets; ENSG00000146386; -.
DR PharmGKB; PA134884626; -.
DR VEuPathDB; HostDB:ENSG00000146386; -.
DR eggNOG; KOG3376; Eukaryota.
DR GeneTree; ENSGT00470000042287; -.
DR HOGENOM; CLU_173478_0_0_1; -.
DR InParanoid; Q9P1F3; -.
DR OMA; QRVHDNV; -.
DR OrthoDB; 1586234at2759; -.
DR PhylomeDB; Q9P1F3; -.
DR PathwayCommons; Q9P1F3; -.
DR SignaLink; Q9P1F3; -.
DR BioGRID-ORCS; 58527; 8 hits in 1079 CRISPR screens.
DR ChiTaRS; ABRACL; human.
DR GenomeRNAi; 58527; -.
DR Pharos; Q9P1F3; Tbio.
DR PRO; PR:Q9P1F3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9P1F3; protein.
DR Bgee; ENSG00000146386; Expressed in monocyte and 171 other tissues.
DR ExpressionAtlas; Q9P1F3; baseline and differential.
DR Genevisible; Q9P1F3; HS.
DR GO; GO:0032970; P:regulation of actin filament-based process; IBA:GO_Central.
DR Gene3D; 1.10.10.1540; -; 1.
DR InterPro; IPR044302; Costars.
DR InterPro; IPR027817; Costars_dom.
DR InterPro; IPR038095; Costars_sf.
DR PANTHER; PTHR46334; PTHR46334; 1.
DR Pfam; PF14705; Costars; 1.
DR SMART; SM01283; Costars; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Direct protein sequencing; Reference proteome.
FT CHAIN 1..81
FT /note="Costars family protein ABRACL"
FT /id="PRO_0000089521"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:25944712"
FT HELIX 3..17
FT /evidence="ECO:0007829|PDB:2L2O"
FT STRAND 24..29
FT /evidence="ECO:0007829|PDB:2L2O"
FT HELIX 30..40
FT /evidence="ECO:0007829|PDB:2L2O"
FT HELIX 46..55
FT /evidence="ECO:0007829|PDB:2L2O"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:2L2O"
FT HELIX 69..71
FT /evidence="ECO:0007829|PDB:2L2O"
FT STRAND 75..78
FT /evidence="ECO:0007829|PDB:2L2O"
SQ SEQUENCE 81 AA; 9056 MW; 1F0DCE7A1D22B171 CRC64;
MNVDHEVNLL VEEIHRLGSK NADGKLSVKF GVLFRDDKCA NLFEALVGTL KAAKRRKIVT
YPGELLLQGV HDDVDIILLQ D
