BMT5_CANAL
ID BMT5_CANAL Reviewed; 612 AA.
AC Q5ALW2; A0A1D8PGF2;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Beta-mannosyltransferase 5;
DE EC=2.4.1.-;
DE AltName: Full=WRY family protein 6;
GN Name=BMT5; Synonyms=IFQ4, WRY6; OrderedLocusNames=CAALFM_C201560WA;
GN ORFNames=CaO19.1464, CaO19.9039;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION.
RX PubMed=18234669; DOI=10.1074/jbc.m708825200;
RA Mille C., Bobrowicz P., Trinel P.A., Li H., Maes E., Guerardel Y.,
RA Fradin C., Martinez-Esparza M., Davidson R.C., Janbon G., Poulain D.,
RA Wildt S.;
RT "Identification of a new family of genes involved in beta-1,2-mannosylation
RT of glycans in Pichia pastoris and Candida albicans.";
RL J. Biol. Chem. 283:9724-9736(2008).
RN [5]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
RN [6]
RP FUNCTION.
RX PubMed=22745283; DOI=10.1093/glycob/cws097;
RA Mille C., Fradin C., Delplace F., Trinel P.A., Masset A., Francois N.,
RA Coddeville B., Bobrowicz P., Jouault T., Guerardel Y., Wildt S., Janbon G.,
RA Poulain D.;
RT "Members 5 and 6 of the Candida albicans BMT family encode enzymes acting
RT specifically on beta-mannosylation of the phospholipomannan cell-wall
RT glycosphingolipid.";
RL Glycobiology 22:1332-1342(2012).
CC -!- FUNCTION: Beta-mannosyltransferase involved in cell wall biosynthesis.
CC Required for beta-1,2-mannose transfer on phospholipomannan.
CC {ECO:0000269|PubMed:22745283}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: Expression is induced in biofilm.
CC {ECO:0000269|PubMed:22265407}.
CC -!- SIMILARITY: Belongs to the BMT family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27202.1; -; Genomic_DNA.
DR RefSeq; XP_722514.1; XM_717421.1.
DR AlphaFoldDB; Q5ALW2; -.
DR SMR; Q5ALW2; -.
DR BioGRID; 1218875; 1.
DR CAZy; GT91; Glycosyltransferase Family 91.
DR GeneID; 3635781; -.
DR KEGG; cal:CAALFM_C201560WA; -.
DR CGD; CAL0000182482; BMT5.
DR VEuPathDB; FungiDB:C2_01560W_A; -.
DR eggNOG; ENOG502QTZG; Eukaryota.
DR HOGENOM; CLU_013841_1_1_1; -.
DR InParanoid; Q5ALW2; -.
DR OMA; KEVWISF; -.
DR OrthoDB; 487566at2759; -.
DR PRO; PR:Q5ALW2; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000030; F:mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0006688; P:glycosphingolipid biosynthetic process; IMP:CGD.
DR InterPro; IPR021988; BMT1.
DR PANTHER; PTHR37989; PTHR37989; 1.
DR Pfam; PF12141; DUF3589; 1.
PE 2: Evidence at transcript level;
KW Cell wall biogenesis/degradation; Glycoprotein; Glycosyltransferase;
KW Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..612
FT /note="Beta-mannosyltransferase 5"
FT /id="PRO_0000426073"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..612
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 480
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 612 AA; 70896 MW; F05BC3888A29A33A CRC64;
MVQKQYRFAP KSIFTFVFLC FVAIVVIIST SSLVQVEESL DPIEVSDEIK KHDRKVVIFP
SNFQSANNKL ADFLTEAFGQ RLNKGDIVYK NRDTYELPQT VYTWNTIDLF QSIGEKDNLK
CEKIPLNFEI SKIYNKNADL YKILRDFKNE NSFYYKEVSV FFPDLGKQLR ERTIEKHWFQ
LIGSSVWLEQ YGVHLMISRV IYTKTGNKVQ PVISLSYVQA FDRNWTELKN VTLVVPDSGK
AKFKTVSYPS FIPIPVYHNV NQQRGKFYGV EDPRIMLVKN KEGYEEPLIV YNSFNRSPPN
ANYLEEIKNL VKLDTYRSIF MAWIWRTQLG KSNVGSSLPD LATTDDHKYV KVKELSLPNK
KRPKTEKNWT PFVIYEDQKK QGYDSHLYFI YSFQDLSILK CSLWDAGNCI WEYRMNNKKT
KISELRGGTE LMNVNQLLDK YNFAGLETVK DQFKGKEVWI SFARAALSKC GCGSKMYRPN
FTVLVKQGGR FQLSFVSSYM DFGVPILPWA KGKGLCNGKN LLIPNGISNW VLAKDEGGGF
QDYMTLSLSR SDSTVDIIHM KGILKSILSE YLLQTNRDVL NNNAIHCALL ESESYCKSYA
ENYRAHLKRW QN
