ID   SYRM1_SINFN             Reviewed;         338 AA.
AC   P55619;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=HTH-type transcriptional regulator SyrM 1;
DE   AltName: Full=Symbiotic regulator homolog 1;
GN   Name=syrM1; OrderedLocusNames=NGR_a01980; ORFNames=y4pN;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
RN   [3]
RP   CHARACTERIZATION.
RA   Hanin M., Jabbouri S., Broughton W.J., Fellay R.;
RT   "SyrM1 of Rhizobium sp. NGR234 activates transcription of symbiotic loci
RT   and controls the level of sulfated Nod factors.";
RL   Mol. Plant Microbe Interact. 11:343-350(1998).
CC   -!- FUNCTION: Transcriptional activator that regulates the expression of
CC       genes involved in symbiosis. Among other targets it acts on the
CC       nolWBTUV operon.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U00090; AAB91824.1; -; Genomic_DNA.
DR   RefSeq; NP_444027.1; NC_000914.2.
DR   RefSeq; WP_010875232.1; NC_000914.2.
DR   AlphaFoldDB; P55619; -.
DR   SMR; P55619; -.
DR   EnsemblBacteria; AAB91824; AAB91824; NGR_a01980.
DR   KEGG; rhi:NGR_a01980; -.
DR   PATRIC; fig|394.7.peg.202; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   OMA; IWHPSRS; -.
DR   OrthoDB; 1591366at2; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nodulation; Plasmid; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..338
FT                   /note="HTH-type transcriptional regulator SyrM 1"
FT                   /id="PRO_0000105754"
FT   DOMAIN          35..92
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        52..72
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   338 AA;  37350 MW;  34AF96921AB9FA73 CRC64;
     MDEPACNGTS NEWQRPQLIV AGPRAARRRQ MLASLDLNTL LALEALLEHR NVTQAARHLG
     LSQPSVSRAL IRLRGVFNDD LLVRGSSGMV PTPHAQRLGQ MLPPVLDSIR GMVDPGLDQG
     EWRLTARMAM PDHQAIVLLP PFLPLMRERA PNLDIVTDSL LALRRLEQGE IDLAVGQIGE
     APPGYFRRRL YNDRFACLLR NGHPALEQES IIDTFSALRH AAIASDTKDG FGRVHDDLVK
     LDLQDPDPVL VSNVLTAGLA IVSTDLVLVV PRRVATRNAA LLPLVIVDPP VELPPYEVAL
     IWHERCHRDP DHRWLRQEIA AAATATEQGQ STDAASRQ