SYRM_RHIME
ID SYRM_RHIME Reviewed; 326 AA.
AC P18561; Q53001;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=HTH-type transcriptional regulator SyrM;
DE AltName: Full=Symbiotic regulator;
GN Name=syrM; OrderedLocusNames=RA0462; ORFNames=SMa0849;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OG Plasmid pSymA (megaplasmid 1).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RCR2011 / SU47;
RX PubMed=2361944; DOI=10.1128/jb.172.7.3695-3700.1990;
RA Barnett M.J., Long S.R.;
RT "DNA sequence and translational product of a new nodulation-regulatory
RT locus: syrM has sequence similarity to NodD proteins.";
RL J. Bacteriol. 172:3695-3700(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AK631;
RX PubMed=1809842; DOI=10.1111/j.1365-2958.1991.tb01863.x;
RA Kondorosi E., Buire M., Cren M., Iyer N., Hoffmann B., Kondorosi A.;
RT "Involvement of the syrM and nodD3 genes of Rhizobium meliloti in nod gene
RT activation and in optimal nodulation of the plant host.";
RL Mol. Microbiol. 5:3035-3048(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481432; DOI=10.1073/pnas.161294798;
RA Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA Long S.R.;
RT "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT meliloti pSymA megaplasmid.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Acts in trans to stimulate nod gene expression via nodD3 and
CC exo gene expression via SyrA.
CC -!- MISCELLANEOUS: Has two translation start codons in proximity to each
CC other leading to a protein of 326 or 301 AA.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA43667.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M33495; AAB38371.1; -; Genomic_DNA.
DR EMBL; X61396; CAA43667.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006469; AAK65120.1; -; Genomic_DNA.
DR PIR; A44505; A44505.
DR PIR; F95319; F95319.
DR PIR; S18575; S18575.
DR RefSeq; NP_435708.1; NC_003037.1.
DR RefSeq; WP_010967445.1; NC_003037.1.
DR AlphaFoldDB; P18561; -.
DR SMR; P18561; -.
DR EnsemblBacteria; AAK65120; AAK65120; SMa0849.
DR GeneID; 61599266; -.
DR KEGG; sme:SMa0849; -.
DR PATRIC; fig|266834.11.peg.473; -.
DR HOGENOM; CLU_039613_39_0_5; -.
DR OMA; VLQQTDM; -.
DR Proteomes; UP000001976; Plasmid pSymA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd08467; PBP2_SyrM; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR037417; SyrM_PBP2.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Nodulation; Plasmid; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..326
FT /note="HTH-type transcriptional regulator SyrM"
FT /id="PRO_0000105753"
FT DOMAIN 32..89
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 49..68
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT CONFLICT 9..24
FT /note="PHRAKFAGVSDAAQQR -> RIGPNLPVSVTPHNK (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="D -> G (in Ref. 2; CAA43667)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 35897 MW; 412F888B1F1FF6C1 CRC64;
MDQPTWKRPH RAKFAGVSDA AQQRQMPNLA SIDLNLLVDL EALLQYRHIT QAAQHVGRSQ
PAMSRALSRL RGMLKDDLLV AGSRGLVLTP LAECLTQMLP SVLDAIRQMM NLSLAPAQRR
WKVTMAMPDH QAVVLLPHLL PRLHERAPHL DIVTDPLLGG ALGLLEQGEI DVVVGQMGAA
PLGYLRRRLY ADSFTCVLRH NHPALAQEWT IEAFAALRHV AIASEPDELF GQIYDRLTKL
GLQRGDPMVV STVLTAAVLI AATDSVLVVP SRVATRVAAM LSLAVIPPPV ELRPYEVALI
WHERCHRDPE HRWLRGEIAA AASTAG
