ID   SYR_AERPE               Reviewed;         644 AA.
AC   Q9YB39;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Arginine--tRNA ligase;
DE            EC=6.1.1.19;
DE   AltName: Full=Arginyl-tRNA synthetase;
DE            Short=ArgRS;
GN   Name=argS; OrderedLocusNames=APE_1756;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; BA000002; BAA80759.1; -; Genomic_DNA.
DR   PIR; B72559; B72559.
DR   AlphaFoldDB; Q9YB39; -.
DR   SMR; Q9YB39; -.
DR   STRING; 272557.APE_1756; -.
DR   EnsemblBacteria; BAA80759; BAA80759; APE_1756.
DR   KEGG; ape:APE_1756; -.
DR   PATRIC; fig|272557.25.peg.1181; -.
DR   eggNOG; arCOG00487; Archaea.
DR   OMA; NKPLHLG; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 2.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..644
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000151642"
FT   MOTIF           129..139
FT                   /note="'HIGH' region"
SQ   SEQUENCE   644 AA;  72173 MW;  076E18F55C0B5A08 CRC64;
     MASSIDPLTR LHGILSSYLS EVLGVDRSVV ERLLAPPPRK EYGDLGFPLM RFARSSNASA
     DSIVESLRGK LWERGITWAS PTLEAGYLNI VFDVEKLGDE VFRLLASGWR PSTARTSRPE
     TIVVEHTSAN PIHPLHLGHA RNSSLGDALA RLLEARGHRV NRRFYVDDVG RQAVVASLGF
     KLSGVTPREL ASRMGVKVDH AVGWVYAVTH NALETVTARK RGDTSKVDEA LSTLARLKER
     GDREVFDRIL EAVGSLDDPE GLVSEMMRKY ERGEEPEKSL IRGVVSAVLE GFRETLGRFG
     VDFDDWDWES DLLWSGLVNK IIEEARRSPF LTTHKDAIAL DIPRIVREVL ARDPEAASTI
     KLPRSLEIPP LILVRSDGTT LYTTRDLAYS VYKFRVTGAD RVINVIGADQ RLPQLQIRLA
     LLGLGYRREA LNMMHYDYEI VSLPGRRMSS RRGEYVTLDE LLEMAKARSV REVESRNPGA
     DRDWIESTAE KIAVGAVRFA LVRPGRLKPI TLDVERILDL KENTAPYLQY TYARASSILE
     KHGEIDYLKA HPASLEEGSR RELFVEALRF PLVSAKAADD LAPEDLASYL LRLADMFNSW
     YQKDSVIHEE WEGARHAKAA LVLLVKSVIG EGLRLLGVEP LEKM