SYR_AGARV
ID SYR_AGARV Reviewed; 597 AA.
AC C4ZD15;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=EUBREC_2239;
OS Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835
OS / VPI 0990) (Eubacterium rectale).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae;
OC Lachnospiraceae incertae sedis.
OX NCBI_TaxID=515619;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / LMG 30912 / VPI
RC 0990;
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR EMBL; CP001107; ACR75978.1; -; Genomic_DNA.
DR RefSeq; WP_012743073.1; NC_012781.1.
DR AlphaFoldDB; C4ZD15; -.
DR SMR; C4ZD15; -.
DR STRING; 515619.EUBREC_2239; -.
DR EnsemblBacteria; ACR75978; ACR75978; EUBREC_2239.
DR KEGG; ere:EUBREC_2239; -.
DR HOGENOM; CLU_006406_5_1_9; -.
DR OMA; HHIGDWG; -.
DR OrthoDB; 1146366at2; -.
DR Proteomes; UP000001477; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00671; ArgRS_core; 1.
DR Gene3D; 3.30.1360.70; -; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR001278; Arg-tRNA-ligase.
DR InterPro; IPR005148; Arg-tRNA-synth_N.
DR InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR11956; PTHR11956; 1.
DR Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF00750; tRNA-synt_1d; 1.
DR PRINTS; PR01038; TRNASYNTHARG.
DR SMART; SM01016; Arg_tRNA_synt_N; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; SSF47323; 1.
DR SUPFAM; SSF55190; SSF55190; 1.
DR TIGRFAMs; TIGR00456; argS; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT CHAIN 1..597
FT /note="Arginine--tRNA ligase"
FT /id="PRO_1000203094"
FT MOTIF 124..134
FT /note="'HIGH' region"
SQ SEQUENCE 597 AA; 66744 MW; C0B7B15F19EABD3A CRC64;
MKKLINLISE EVTKAFVSAG YDEKYGKVTL SNRPDLCEFQ CNGAMAAAKE YKCAPFMISD
KVAALLESDE MFESVESVKP GFLNIKMDTA FLAKYMNDMK DDEGRYGLEK AKKPLTIVVD
YGGPNVAKPL HVGHLRSAVI GESVKRIAKF MGHNVIGDVH LGDWGLQMGL IITELRERKP
DLVYFDESYT GEYPKEAPFT ISELEDIYPT ASGKSKSDES FKEAALLATK ELQGGRRGYQ
ALLSHIMNVS VTDLKRNYEN LNVHFELWKG ESDAQPYVPG MVEMMKEKGF AHMSEGALVV
DVKEDTDTKE IPPCIILKSD GASLYSTTDL ATLVMRMKEN NPDRVIYLAD ARQSMHFIQV
FRCARKTGIV PDTTELVHIG FGTMNGKDGK PFKTRDGGVM RLEYLLKEID DEMLNKIKEN
QKEKENLNID EAEAEQTAKT VALAAVKYGD LSNQASKDYI FDIDRFTSFE GNTGPYILYT
IVRIKSILSK YEAKGGDISA LKDAIMPAVN AGQKNLMLSL AKFNATIESA YEESAPHKIC
AYIYELANAF NGFYHDTKIL SEENEELKKS YISLLVLTKE ILEACIDMLG FSAPDRM