SYR_BARHE
ID SYR_BARHE Reviewed; 585 AA.
AC Q6G316;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=BH09980;
OS Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS (Rochalimaea henselae).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=283166;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA La Scola B., Holmberg M., Andersson S.G.E.;
RT "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT of the zoonotic agent Bartonella henselae.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR EMBL; BX897699; CAF27790.1; -; Genomic_DNA.
DR RefSeq; WP_011180864.1; NZ_LRIJ02000001.1.
DR AlphaFoldDB; Q6G316; -.
DR SMR; Q6G316; -.
DR STRING; 283166.BH09980; -.
DR PaxDb; Q6G316; -.
DR PRIDE; Q6G316; -.
DR EnsemblBacteria; CAF27790; CAF27790; BH09980.
DR GeneID; 64157209; -.
DR KEGG; bhe:BH09980; -.
DR eggNOG; COG0018; Bacteria.
DR OMA; NKPLHLG; -.
DR Proteomes; UP000000421; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00671; ArgRS_core; 1.
DR Gene3D; 3.30.1360.70; -; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR001278; Arg-tRNA-ligase.
DR InterPro; IPR005148; Arg-tRNA-synth_N.
DR InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR11956; PTHR11956; 1.
DR Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF00750; tRNA-synt_1d; 2.
DR PRINTS; PR01038; TRNASYNTHARG.
DR SMART; SM01016; Arg_tRNA_synt_N; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; SSF47323; 1.
DR SUPFAM; SSF55190; SSF55190; 1.
DR TIGRFAMs; TIGR00456; argS; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis.
FT CHAIN 1..585
FT /note="Arginine--tRNA ligase"
FT /id="PRO_0000241988"
FT MOTIF 131..141
FT /note="'HIGH' region"
SQ SEQUENCE 585 AA; 66328 MW; 0A069C7C8C5846BB CRC64;
MNVFKNFEKK IKKSLESSDI KGKNGEDLDL SKITVDPPRD SSHGHLSTNA AMVLAKSTGL
NPRALAEKII ELLKNDPSVE SINVAGPGFI NIKLTKPFWQ DLIKSMLEKG ISYGRIPMGQ
GKRINVEYVS ANPTGPMHVG HCRGAVVGDV LSNLLQFVGY NITKEYYIND AGKQIEVLAH
SVLLRYREAL GQKINEIPEG LYPGEYLIPL GQSLAQEFGD KLLTIDKEEA LSIVKERAIH
EMMSMIRKDL AALNIYHDIF FSERMLYADN ARAIRNTIND LTLKGYIYKG KLPPPKGQNT
EDWEPCEQTL FRSTDVGDDQ DRVLIKSDGS YTYFAADVAY FRDKFNRHFD EMIYILGADH
AGYVKRLEAM AKAISNDKAK LSVFLCQLVK LFRNGHPVRM SKRAGSFVTL RDVVEEVGSD
PVRFMMLYRK CEAPLDFDFA KVTEQSKDNP IFYVQYASAR CHSVFRQAQE TLCIENISND
KIIEHLNRLT DDNEIFLIRK LSEYPRIIEQ AVVHKEPHRL AFYLYDLASS FHTHWNKGSD
NLNLRFIQPD DRNLSFARLG LIQAIMNILS SGLAIVGIKA ATEMR