ID   BMTI2_RHIMP             Reviewed;          25 AA.
AC   P83603;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Kunitz-type serine protease inhibitor 2;
DE            Short=BmTI-2;
DE   Flags: Fragment;
OS   Rhipicephalus microplus (Cattle tick) (Boophilus microplus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Boophilus.
OX   NCBI_TaxID=6941;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Larva;
RX   PubMed=15556274; DOI=10.1016/j.biochi.2004.09.010;
RA   Sasaki S.D., Azzolini S.S., Hirata I.Y., Andreotti R., Tanaka A.S.;
RT   "Boophilus microplus tick larvae, a rich source of Kunitz type serine
RT   proteinase inhibitors.";
RL   Biochimie 86:643-649(2004).
CC   -!- FUNCTION: Inhibits bovine trypsin, human plasma kallikrein and human
CC       neutrophil elastase. {ECO:0000269|PubMed:15556274}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   AlphaFoldDB; P83603; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..>25
FT                   /note="Kunitz-type serine protease inhibitor 2"
FT                   /id="PRO_0000155451"
FT   DOMAIN          6..>25
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            17..18
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2691 MW;  D8E538C2C2B20466 CRC64;
     VTIGPVCELP KEVGGPCRGH IIPRY