ID   SYR_CHLAA               Reviewed;         574 AA.
AC   A9WEH7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=Caur_2024;
OS   Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=324602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29366 / DSM 635 / J-10-fl;
RX   PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA   Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA   Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA   Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT   "Complete genome sequence of the filamentous anoxygenic phototrophic
RT   bacterium Chloroflexus aurantiacus.";
RL   BMC Genomics 12:334-334(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; CP000909; ABY35239.1; -; Genomic_DNA.
DR   RefSeq; WP_012257893.1; NC_010175.1.
DR   RefSeq; YP_001635628.1; NC_010175.1.
DR   AlphaFoldDB; A9WEH7; -.
DR   SMR; A9WEH7; -.
DR   STRING; 324602.Caur_2024; -.
DR   PRIDE; A9WEH7; -.
DR   EnsemblBacteria; ABY35239; ABY35239; Caur_2024.
DR   KEGG; cau:Caur_2024; -.
DR   PATRIC; fig|324602.8.peg.2300; -.
DR   eggNOG; COG0018; Bacteria.
DR   HOGENOM; CLU_006406_5_1_0; -.
DR   InParanoid; A9WEH7; -.
DR   OMA; NKPLHLG; -.
DR   Proteomes; UP000002008; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..574
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_1000095347"
FT   MOTIF           126..136
FT                   /note="'HIGH' region"
SQ   SEQUENCE   574 AA;  63529 MW;  888BC5FA56D9BB46 CRC64;
     MRYALERFIS DIQAAIVATG KVPADLIEIT TPKPNIPADR TFVTFKAAKA LGVDPVRLAA
     DLATAIVPPP DSLIGEVTAT GAFLNFTLHP QRLAAAVMAE IETYGDAYGS VADGANRTVV
     IDYSSPNIAK RMHVGHIRST IIGQALVHIF RALGYRVIGD NHLGDWGTQF GIILAAMQRY
     GRPQNEGEAA MAELEALYAR YNAEMKDNPP LEDEARRWSL ALEQGDPTAR ELWQWCVDLT
     MRAAQRNYDR LGVRFDYAYG ESFYEAMLPG VIEEALQSGA AFRDVDGAVV AELDKLPRFI
     VQRSDGGTVY ITRDIATIKF RLQEFNPSHI IYVVDARQEL HFRQLFAIVR AMGYALDVEL
     IHVPFGVITT PDGQPLSTKK GNMVYLESLL DDAVARARAL VDAKSPTLSP EERAQIAEAV
     GIGAVIYNDL YQDPRRNITL DWDRMLSIEG NSAAYLQYSH ARCRSILRRA AEEGMLSTEV
     DPGLLTHPSE QRLVRHLARL PEAVREAGAR YAPFVIADWC YTTAREFGIF FEQCPVLRAE
     TPALRAARLQ LVSATANALR NGLALLGIQA PERM