SYR_CHLP8
ID SYR_CHLP8 Reviewed; 551 AA.
AC B3QLU7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=Cpar_2046;
OS Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) (Chlorobium vibrioforme
OS subsp. thiosulfatophilum).
OC Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX NCBI_TaxID=517417;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 263 / NCIMB 8327;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z., Overmann J.,
RA Bryant D.A., Richardson P.;
RT "Complete sequence of Chlorobaculum parvum NCIB 8327.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR EMBL; CP001099; ACF12433.1; -; Genomic_DNA.
DR RefSeq; WP_012503266.1; NC_011027.1.
DR AlphaFoldDB; B3QLU7; -.
DR SMR; B3QLU7; -.
DR STRING; 517417.Cpar_2046; -.
DR EnsemblBacteria; ACF12433; ACF12433; Cpar_2046.
DR KEGG; cpc:Cpar_2046; -.
DR eggNOG; COG0018; Bacteria.
DR HOGENOM; CLU_006406_0_1_10; -.
DR OMA; NKPLHLG; -.
DR OrthoDB; 1146366at2; -.
DR Proteomes; UP000008811; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00671; ArgRS_core; 1.
DR Gene3D; 3.30.1360.70; -; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR InterPro; IPR001278; Arg-tRNA-ligase.
DR InterPro; IPR005148; Arg-tRNA-synth_N.
DR InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR11956; PTHR11956; 1.
DR Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF00750; tRNA-synt_1d; 1.
DR PRINTS; PR01038; TRNASYNTHARG.
DR SMART; SM01016; Arg_tRNA_synt_N; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; SSF47323; 1.
DR SUPFAM; SSF55190; SSF55190; 1.
DR TIGRFAMs; TIGR00456; argS; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis.
FT CHAIN 1..551
FT /note="Arginine--tRNA ligase"
FT /id="PRO_1000095349"
FT MOTIF 123..133
FT /note="'HIGH' region"
SQ SEQUENCE 551 AA; 61729 MW; DBB70365D97AEC2A CRC64;
MRAFFLPFIQ DALHKAGIET DKEIQIDKPN DKKFGDFSTN IAFLLAKEAR KNPRELATQL
IGLFAFPEGT VTKTEVAGPG FINFHLAPAF FMRSAQEVLT QGEKFGCTES GKGQKAIVEY
VSANPTGPLT IGRGRGGVLG DCIANLLETQ GYEVTREYYF NDAGRQMQIL AESVRYRYLE
KCGQTVEFPE THYQGDYIGE IAGTLFIEHS DELASSDELG IFKETAEAVI FSSIRRTLER
IGITHDSFFN EHTLYQWNEG EASGNQKVID ALEAKDFIGR YDGATWFMTT KLGQEKDKVL
IKSSGDPSYR LPDIAYHVTK FERGFDLMVN VFGADHIDEY PDVLEALKIL GYDASKVKIA
INQFVTTTVG GQTVKMSTRK GNADLLDDLI EDVGADATRL FFIMRSKDSH LNFDVELAKK
QSKDNPVFYL QYAHARICSL VRLAEKEVGF DEAAATGASL PLLDSEPEID LASALLDFPD
VIQSCLRLLE PQKMVEYLHT VAERYHKFYQ ECPILKADEN IRTARLELSL TVRQVLRNGF
RILGISAPES M