SYR_CHLPN
ID SYR_CHLPN Reviewed; 561 AA.
AC Q9Z7Y3; Q9JQ78;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Arginine--tRNA ligase;
DE EC=6.1.1.19;
DE AltName: Full=Arginyl-tRNA synthetase;
DE Short=ArgRS;
GN Name=argS; OrderedLocusNames=CPn_0570, CP_0179, CpB0593;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC EC=6.1.1.19;
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000305}.
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DR EMBL; AE001363; AAD18710.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38053.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98776.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98521.1; -; Genomic_DNA.
DR PIR; C72063; C72063.
DR PIR; F86561; F86561.
DR RefSeq; NP_224766.1; NC_000922.1.
DR RefSeq; WP_010883208.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z7Y3; -.
DR SMR; Q9Z7Y3; -.
DR STRING; 115711.CP_0179; -.
DR EnsemblBacteria; AAD18710; AAD18710; CPn_0570.
DR EnsemblBacteria; AAF38053; AAF38053; CP_0179.
DR GeneID; 45050614; -.
DR KEGG; cpa:CP_0179; -.
DR KEGG; cpj:argS; -.
DR KEGG; cpn:CPn_0570; -.
DR KEGG; cpt:CpB0593; -.
DR PATRIC; fig|115713.3.peg.635; -.
DR eggNOG; COG0018; Bacteria.
DR HOGENOM; CLU_006406_5_1_0; -.
DR OrthoDB; 1146366at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR CDD; cd00671; ArgRS_core; 1.
DR Gene3D; 3.30.1360.70; -; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR001278; Arg-tRNA-ligase.
DR InterPro; IPR005148; Arg-tRNA-synth_N.
DR InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR11956; PTHR11956; 1.
DR Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF00750; tRNA-synt_1d; 1.
DR PRINTS; PR01038; TRNASYNTHARG.
DR SMART; SM01016; Arg_tRNA_synt_N; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; SSF47323; 1.
DR SUPFAM; SSF55190; SSF55190; 1.
DR TIGRFAMs; TIGR00456; argS; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW Nucleotide-binding; Protein biosynthesis.
FT CHAIN 1..561
FT /note="Arginine--tRNA ligase"
FT /id="PRO_0000151546"
FT MOTIF 123..133
FT /note="'HIGH' region"
SQ SEQUENCE 561 AA; 63369 MW; 6386F0FF190C22DB CRC64;
MSTLLSILSV ICSQAIAKAF PNLEDWAPEI TPSTKEHFGH YQCNDAMKLA RVLKKAPRAI
AEAIVAELPQ EPFSLIEIAG AGFINFTFSP VFLNQQLEHF KDALKLGFQV SQPKKIIIDF
SSPNIAKDMH VGHLRSTIIG DSLARIFSYV GHDVLRLNHI GDWGTAFGML ITYLQENPCD
YSDLEDLTSL YKKAYVCFTN DEEFKKRSQQ NVVALQAKDP QAIAIWEKIC ETSEKAFQKI
YDILDIVVEK RGESFYNPFL PEIIEDLEKK GLLTVSNDAK CVFHEAFSIP FMVQKSDGGY
NYATTDLAAM RYRIEEDHAD KIIIVTDLGQ SLHFQLLEAT AIAAGYLQPG IFSHVGFGLV
LDPQGKKLKT RSGENVKLRE LLDTAIEKAE EALREHRPEL TDEAIQERAP VIGINAIKYS
DLSSHRTSDY VFSFEKMLRF EGNTAMFLLY AYVRIQGIKR RLGISQLSLE GPPEIQEPAE
ELLALTLLRF PEALESTIKE LCPHFLTDYL YNLTHKFNGF FRDSHIQDSP YAKSRLFLCA
LAEQVLATGM HLLGLKTLER L
