BNB_DROME
ID BNB_DROME Reviewed; 442 AA.
AC P29746; A4V4R4; Q0KHQ7; Q9VWQ0;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein bangles and beads;
GN Name=bnb; ORFNames=CG7088;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=2693037; DOI=10.1242/dev.105.3.629;
RA Ng S.C., Perkins L.A., Conboy G., Perrimon N., Fishman M.C.;
RT "A Drosophila gene expressed in the embryonic CNS shares one conserved
RT domain with the mammalian GAP-43.";
RL Development 105:629-638(1989).
RN [2]
RP SEQUENCE REVISION.
RC TISSUE=Embryo;
RX PubMed=1551578; DOI=10.1093/genetics/130.3.569;
RA Eberl D.F., Perkins L.A., Engelstein M., Hilliker A.J., Perrimon N.;
RT "Genetic and developmental analysis of polytene section 17 of the X
RT chromosome of Drosophila melanogaster.";
RL Genetics 130:569-583(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430; SER-433; SER-436 AND
RP SER-437, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May play an important role during development.
CC {ECO:0000269|PubMed:2693037}.
CC -!- TISSUE SPECIFICITY: Expressed in the embryonic CNS, in sets of cells
CC that are segmentally reiterated along the periphery of the nervous
CC system. {ECO:0000269|PubMed:2693037}.
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DR EMBL; X63828; CAA45323.1; -; mRNA.
DR EMBL; AE014298; AAN09476.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09477.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09478.1; -; Genomic_DNA.
DR EMBL; AY060682; AAL28230.1; -; mRNA.
DR PIR; A43555; A43555.
DR RefSeq; NP_523406.1; NM_078682.4.
DR RefSeq; NP_728201.1; NM_167633.2.
DR RefSeq; NP_728202.1; NM_167634.3.
DR RefSeq; NP_728203.1; NM_167635.3.
DR AlphaFoldDB; P29746; -.
DR BioGRID; 59181; 8.
DR DIP; DIP-21221N; -.
DR IntAct; P29746; 3.
DR STRING; 7227.FBpp0074427; -.
DR iPTMnet; P29746; -.
DR PaxDb; P29746; -.
DR PRIDE; P29746; -.
DR DNASU; 32872; -.
DR EnsemblMetazoa; FBtr0074656; FBpp0074427; FBgn0001090.
DR EnsemblMetazoa; FBtr0074657; FBpp0074428; FBgn0001090.
DR EnsemblMetazoa; FBtr0074658; FBpp0074429; FBgn0001090.
DR EnsemblMetazoa; FBtr0074659; FBpp0074430; FBgn0001090.
DR GeneID; 32872; -.
DR KEGG; dme:Dmel_CG7088; -.
DR CTD; 32872; -.
DR FlyBase; FBgn0001090; bnb.
DR VEuPathDB; VectorBase:FBgn0001090; -.
DR eggNOG; ENOG502T8DV; Eukaryota.
DR HOGENOM; CLU_036657_0_0_1; -.
DR InParanoid; P29746; -.
DR OMA; PAVNGEC; -.
DR OrthoDB; 1307063at2759; -.
DR PhylomeDB; P29746; -.
DR SignaLink; P29746; -.
DR BioGRID-ORCS; 32872; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32872; -.
DR PRO; PR:P29746; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0001090; Expressed in head capsule and 59 other tissues.
DR Genevisible; P29746; DM.
DR GO; GO:0042063; P:gliogenesis; IEP:FlyBase.
DR GO; GO:0007275; P:multicellular organism development; IMP:FlyBase.
PE 1: Evidence at protein level;
KW Developmental protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..442
FT /note="Protein bangles and beads"
FT /id="PRO_0000064955"
FT REGION 47..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 433
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 436
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 437
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 442 AA; 45816 MW; 8EB67F77656A1200 CRC64;
MKCQLLFVAT VCLASVWALP VPDEEVAIQP DSGAKAELLT KTVLPTAVEP APLKPEAEKP
AETKTIEAKA AVPEQPDVNA NPSPSTPAAE PAKEINSVEL KSSAPDVETA PAIPEKKTLP
EEAKPAQENA PVEAEKKQEK TARTEAEPTV EAQPQATKAI EQAPEAPAAN AEVQKQVVDE
VKPQEPKIDA KSAEEPAIPA VVAAEKETPV PEQPARQERI NEIEQKDAKK DAAVAEEPAK
AAEATPTAAP EAATKSDSNI QVIAPEKKSI ESSPAAAAAS PAAQAAQAKS GEAPKPVDQQ
KSTETVAESA PVLKTNAPLA PAGATKVTEA VKEQEKEQPA ADTAAKALPE QKKTEETAAP
AGAPEPTAAV APAAVPEAKK IDEAPAAETV VKGEEAIAKP IAQSPSAEPK KSSEEKSDKS
ESKVDESSES KESEESSESK EN
