ID   SYR_KORCO               Reviewed;         632 AA.
AC   B1L3E4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=Kcr_0213;
OS   Korarchaeum cryptofilum (strain OPF8).
OC   Archaea; Candidatus Korarchaeota; Candidatus Korarchaeum.
OX   NCBI_TaxID=374847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OPF8;
RX   PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA   Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA   Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA   Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA   Richardson P., Keller M., Stetter K.O.;
RT   "A korarchaeal genome reveals new insights into the evolution of the
RT   Archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; CP000968; ACB06973.1; -; Genomic_DNA.
DR   RefSeq; WP_012308870.1; NC_010482.1.
DR   AlphaFoldDB; B1L3E4; -.
DR   SMR; B1L3E4; -.
DR   STRING; 374847.Kcr_0213; -.
DR   PRIDE; B1L3E4; -.
DR   EnsemblBacteria; ACB06973; ACB06973; Kcr_0213.
DR   GeneID; 6093502; -.
DR   KEGG; kcr:Kcr_0213; -.
DR   eggNOG; arCOG00487; Archaea.
DR   HOGENOM; CLU_006406_6_1_2; -.
DR   InParanoid; B1L3E4; -.
DR   OMA; NKPLHLG; -.
DR   OrthoDB; 7046at2157; -.
DR   PhylomeDB; B1L3E4; -.
DR   Proteomes; UP000001686; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IBA:GO_Central.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 2.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..632
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_1000095374"
FT   MOTIF           129..139
FT                   /note="'HIGH' region"
SQ   SEQUENCE   632 AA;  71667 MW;  751ACAF493D4691C CRC64;
     MIKDPLGAVK STFAEEVNRV LRDLGSATRF SPIQVSRVRK DYASYGLPVG FKVAKDLNLD
     PERAAKTVLD RIDMSRIAYS SDAYAESGYL NLRIDKARFF RDILKLASSE ELGRGERKGV
     VGMVEHTSAN PVHPLHVGSG RNAVIGDSFS RILNFLGWDV RRHYLVNDCN LQVAILAAGR
     SKVRDLIPKG KVDHWFGLIY AISNAFLEIW RIKNGFNSES KIEEWSEVVE RIGRMEPELL
     RIGELSEEEV MSLLREYQRK EGGSVQMFRE ITESVLRGFV ETLERMGITY DSFDRESELI
     WDGWVDRAIE KLESSGYLKR EGKAAYVDLW EAAKGDENVR KVFELSEDDI SKLEREGKLG
     EVIPRKFYLT RSDGTWLYTG TDVAYSLYKF DGLGVSFCYN VIASEQNMEQ KGVRACLALM
     GHDPGKLIHL SYEMVNLVGA AMSGRRGLYI TLDEVLDEAK RRVEAILKER GIYDEEICEK
     VAIGALKYGL ISVSPNKVVQ FRWERVLNLE ENSGPFIQYA YTRALNIIKK AQGVPEDFDP
     NELKSDAEIT IVQMISEFPE RVWSAFNLMR PDIIASYANE LASQFNKFYE DHPVLSAARP
     EERAARLNLV NAVKGTLGLA MDLIGIPRLE RM