BNCH_CAEEL
ID BNCH_CAEEL Reviewed; 205 AA.
AC Q1ZXU0;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Basonuclin zinc finger protein homolog {ECO:0000305};
GN Name=bnc-1 {ECO:0000312|WormBase:F55C5.11};
GN ORFNames=F55C5.11 {ECO:0000312|WormBase:F55C5.11};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF 32-GLN--VAL-205 AND CYS-137.
RX PubMed=28056346; DOI=10.1016/j.neuron.2016.11.036;
RA Kerk S.Y., Kratsios P., Hart M., Mourao R., Hobert O.;
RT "Diversification of C. elegans Motor Neuron Identity via Selective Effector
RT Gene Repression.";
RL Neuron 93:80-98(2017).
CC -!- FUNCTION: Probable transcription factor (PubMed:28056346). Involved in
CC motor neuron fate determination and maintenance, acting as a
CC transcriptional repressor to counteract gene activation by
CC transcription factor unc-3 in a subset of motor neurons
CC (PubMed:28056346). Required throughout development to repress
CC transcription by unc-3, probably acting by binding to specific promoter
CC elements (PubMed:28056346). Represses expression of DA and DB motor
CC neuron-specific effector genes, such as unc-129 and unc-53, in VA and
CC VB motor neurons (PubMed:28056346). {ECO:0000269|PubMed:28056346}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28056346}.
CC -!- TISSUE SPECIFICITY: Expressed in the VA and VB motor neurons and at
CC lower levels in the SABV neuron pair. {ECO:0000269|PubMed:28056346}.
CC -!- DEVELOPMENTAL STAGE: Expression begins around the postembryonic birth
CC of VA and VB motor neurons at the late first larval L1 stage, and is
CC maintained throughout the life of the animals.
CC {ECO:0000269|PubMed:28056346}.
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DR EMBL; BX284605; CAJ85750.1; -; Genomic_DNA.
DR RefSeq; NP_001041125.1; NM_001047660.3.
DR AlphaFoldDB; Q1ZXU0; -.
DR STRING; 6239.F55C5.11; -.
DR PaxDb; Q1ZXU0; -.
DR EnsemblMetazoa; F55C5.11.1; F55C5.11.1; WBGene00044791.
DR GeneID; 4363106; -.
DR KEGG; cel:CELE_F55C5.11; -.
DR UCSC; F55C5.11; c. elegans.
DR CTD; 4363106; -.
DR WormBase; F55C5.11; CE40071; WBGene00044791; bnc-1.
DR eggNOG; ENOG502QR8N; Eukaryota.
DR GeneTree; ENSGT00390000005844; -.
DR HOGENOM; CLU_1338631_0_0_1; -.
DR InParanoid; Q1ZXU0; -.
DR OMA; LREMHTC; -.
DR OrthoDB; 96985at2759; -.
DR PhylomeDB; Q1ZXU0; -.
DR PRO; PR:Q1ZXU0; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00044791; Expressed in larva.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR040436; Disconnected-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15021; PTHR15021; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..205
FT /note="Basonuclin zinc finger protein homolog"
FT /id="PRO_0000455336"
FT ZN_FING 107..130
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 135..164
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 145..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 32..205
FT /note="Missing: In ot763; Induces ectopic expression of
FT unc-129 and unc-53 in ventral nerve cord motor neurons
FT (MNs)."
FT /evidence="ECO:0000269|PubMed:28056346"
FT MUTAGEN 137
FT /note="C->Y: In ot721; Induces ectopic expression of unc-
FT 129, unc-53, acr-16 and unc-8 in ventral nerve cord motor
FT neurons (MNs) VA and VB. In an unc-3 mutant background,
FT both normal and ectopic expression of unc-129 in ventral
FT nerve cord MNs is abolished."
FT /evidence="ECO:0000269|PubMed:28056346"
SQ SEQUENCE 205 AA; 23144 MW; 76126AE0ACFBB8A5 CRC64;
MDVRFPPYIF SMPHLIYNSW LSLNAPKLAQ LQLQSIKLVG QDKSINQSEL PVNSENISIR
VETETNIDSL AKEEKLSEHV HDEKADKIEK TSEDNDTSTL LKLKRRVACD ICSKSFCDKG
ALKIHTSAVH LREMHTCTVT GCGKQFSSRR SRNRHSSNNN PKLHMPESLT LTGSGLSMKT
SLDTFWPTRF LLGKDHPLDL SLNLV
