ID   SYR_METAR               Reviewed;         563 AA.
AC   Q0W6L7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=UNCMA_22090;
GN   ORFNames=RCIX568;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; AM114193; CAJ35976.1; -; Genomic_DNA.
DR   RefSeq; WP_012036529.1; NC_009464.1.
DR   AlphaFoldDB; Q0W6L7; -.
DR   SMR; Q0W6L7; -.
DR   STRING; 351160.RCIX568; -.
DR   EnsemblBacteria; CAJ35976; CAJ35976; RCIX568.
DR   GeneID; 5144438; -.
DR   KEGG; rci:RCIX568; -.
DR   PATRIC; fig|351160.9.peg.2259; -.
DR   eggNOG; arCOG00487; Archaea.
DR   OMA; NKPLHLG; -.
DR   OrthoDB; 7046at2157; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..563
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_1000018142"
FT   MOTIF           119..129
FT                   /note="'HIGH' region"
SQ   SEQUENCE   563 AA;  63244 MW;  B6BE5762112717D7 CRC64;
     MYLKLLEEAG RLMKQAVADA GYTVEDMSLV ESQHADVSSS LPFRLAKELK KNPKEIAAAI
     VEKMGKSEYI DRVEATGAYI NFYASQKYIT DSLKEILSEK KFFELEPNGI KVILEHTSAN
     PTGPLHVGRG RNPIIGDTLA RLLRAGGYDL EVQYYVDDMG KQEATIVWGY DHLDRIKPGK
     PDTDKPDHEI VEVYRAATDL RKSDEAVEKE ISEILNAYEH MDPATAVKFR EMVERCLEGQ
     KMTLARMNVF YDRFVWESDF VRDGSVNKAV KKLAESQYAT TKDGALALDL SSFGMDKEFV
     LTRADGTSLY TTRDIAFHVW KLARCDRAIN VLGEDQKLAM QRLNAALSIL GEKKAPTIVF
     YSFVSLPEGR MSTRKGVVVN LDDLLDEAVE RAYVEVDKRR KDIPEEKKRQ IAEAVGIGAV
     RFDIVRVAPE KSITFKWETA LDFEKQGAPF IQYAHARCCS ILEKAKPGEY DASMLREPEE
     AALVKKIAMM PYVIKNASTE LKPHVIAIYA RELAEAFNQF YRVSPVLIAE PELKEARLAL
     VEASRKALAA SLGMLGIAAI EEM