BND7A_DROME
ID BND7A_DROME Reviewed; 505 AA.
AC Q9VZA4; Q5BI93; Q8IRA9; Q8T0L0; Q95SR9; Q9VZA3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Band 7 protein CG42540;
GN ORFNames=CG42540;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF47920.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF47920.2}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL28172.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B), AND RNA EDITING
RP OF POSITION 297.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL28172.1};
RC TISSUE=Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAX33479.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAX33479.1}; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP RNA EDITING OF POSITION 297.
RX PubMed=17018572; DOI=10.1261/rna.254306;
RA Stapleton M., Carlson J.W., Celniker S.E.;
RT "RNA editing in Drosophila melanogaster: new targets and functional
RT consequences.";
RL RNA 12:1922-1932(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=B {ECO:0000269|PubMed:10731132};
CC IsoId=Q9VZA4-1; Sequence=Displayed;
CC Name=A {ECO:0000269|PubMed:10731132};
CC IsoId=Q9VZA4-2; Sequence=VSP_052614, VSP_052615;
CC Name=C {ECO:0000269|PubMed:10731132};
CC IsoId=Q9VZA4-3; Sequence=VSP_052613, VSP_052616;
CC Name=F;
CC IsoId=Q9VZA4-4; Sequence=VSP_037881;
CC -!- RNA EDITING: Modified_positions=297 {ECO:0000269|PubMed:12537569,
CC ECO:0000269|PubMed:17018572}; Note=Partially edited. Target of Adar.
CC {ECO:0000269|PubMed:17018572};
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000255}.
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DR EMBL; AE014296; AAF47920.2; -; Genomic_DNA.
DR EMBL; AE014296; AAF47921.3; -; Genomic_DNA.
DR EMBL; AE014296; AAN11610.2; -; Genomic_DNA.
DR EMBL; AY060624; AAL28172.1; -; mRNA.
DR EMBL; AY069196; AAL39341.1; -; mRNA.
DR EMBL; BT021331; AAX33479.1; -; mRNA.
DR RefSeq; NP_647917.3; NM_139660.5. [Q9VZA4-2]
DR RefSeq; NP_729016.2; NM_168095.3. [Q9VZA4-3]
DR RefSeq; NP_729018.1; NM_168096.3. [Q9VZA4-1]
DR AlphaFoldDB; Q9VZA4; -.
DR SMR; Q9VZA4; -.
DR BioGRID; 64036; 1.
DR IntAct; Q9VZA4; 5.
DR STRING; 7227.FBpp0293525; -.
DR PaxDb; Q9VZA4; -.
DR DNASU; 38562; -.
DR EnsemblMetazoa; FBtr0301095; FBpp0290317; FBgn0260657. [Q9VZA4-1]
DR EnsemblMetazoa; FBtr0301096; FBpp0290318; FBgn0260657. [Q9VZA4-3]
DR EnsemblMetazoa; FBtr0301097; FBpp0290319; FBgn0260657. [Q9VZA4-2]
DR EnsemblMetazoa; FBtr0301098; FBpp0290320; FBgn0260657. [Q9VZA4-4]
DR GeneID; 38562; -.
DR KEGG; dme:Dmel_CG42540; -.
DR UCSC; CG32245-RA; d. melanogaster. [Q9VZA4-1]
DR FlyBase; FBgn0260657; CG42540.
DR VEuPathDB; VectorBase:FBgn0260657; -.
DR eggNOG; KOG2621; Eukaryota.
DR GeneTree; ENSGT01030000234614; -.
DR InParanoid; Q9VZA4; -.
DR PhylomeDB; Q9VZA4; -.
DR Reactome; R-DME-2672351; Stimuli-sensing channels.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-8980692; RHOA GTPase cycle.
DR Reactome; R-DME-9013026; RHOB GTPase cycle.
DR Reactome; R-DME-9013106; RHOC GTPase cycle.
DR Reactome; R-DME-9013407; RHOH GTPase cycle.
DR BioGRID-ORCS; 38562; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG42540; fly.
DR GenomeRNAi; 38562; -.
DR PRO; PR:Q9VZA4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0260657; Expressed in brain and 10 other tissues.
DR ExpressionAtlas; Q9VZA4; baseline and differential.
DR Genevisible; Q9VZA4; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR043202; Band-7_stomatin-like.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR018080; Band_7/stomatin-like_CS.
DR InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR PANTHER; PTHR10264; PTHR10264; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00721; STOMATIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
DR PROSITE; PS01270; BAND_7; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; RNA editing;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..505
FT /note="Band 7 protein CG42540"
FT /id="PRO_0000311707"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 2..163
FT /note="PDSMMDMEHRDHQLHRQQQQSHHHQPPRLTASTSTFAPPAPAGSQSEERDRD
FT RDRERDHHLHHHQSNNVASSPLPVTASIQLHQQQPQQQQQQQPLTQLQQPQLREREHHQ
FT QQQQQQQQMMQQPQQQQQMQQPQQQLPHSHHALMQQSQQQQAIHRAEARRA -> AAMS
FT ADIVPMEQVSSMVSNGGGSVAMQRDDEYRNRIMKIRRLGLLQSIKISDRTDSLWQVTAT
FT SMQQPPPQRHGRPAPQHQHSQHNQHHQHQNQWALHHQNHLNQTPRSTGRQTMLGSNHSS
FT QRETSVSPRRVALDTTASGSTTGFGFDRDTQAKHSHGFLYS (in isoform F)"
FT /evidence="ECO:0000305"
FT /id="VSP_037881"
FT VAR_SEQ 2..56
FT /note="PDSMMDMEHRDHQLHRQQQQSHHHQPPRLTASTSTFAPPAPAGSQSEERDRD
FT RDR -> AAMSADIVPMEQVSSMVSNGGGSVAMQRDDEYRNRIMKIRRLDTQAKHSHGF
FT LYS (in isoform C)"
FT /evidence="ECO:0000303|PubMed:10731132, ECO:0000303|Ref.4"
FT /id="VSP_052613"
FT VAR_SEQ 2..54
FT /note="PDSMMDMEHRDHQLHRQQQQSHHHQPPRLTASTSTFAPPAPAGSQSEERDRD
FT R -> VEEFLEKLPEIDTRYEDIVPMEQVSSMVSNGGGSVAMQRDDEYRNRIMKIRRL
FT (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_052614"
FT VAR_SEQ 55..162
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_052615"
FT VAR_SEQ 57..163
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:10731132, ECO:0000303|Ref.4"
FT /id="VSP_052616"
FT VARIANT 297
FT /note="N -> D (in RNA edited version)"
FT /evidence="ECO:0000269|PubMed:17018572"
SQ SEQUENCE 505 AA; 57526 MW; B28F6B807CFC7FE5 CRC64;
MPDSMMDMEH RDHQLHRQQQ QSHHHQPPRL TASTSTFAPP APAGSQSEER DRDRDRERDH
HLHHHQSNNV ASSPLPVTAS IQLHQQQPQQ QQQQQPLTQL QQPQLREREH HQQQQQQQQQ
MMQQPQQQQQ MQQPQQQLPH SHHALMQQSQ QQQAIHRAEA RRADEEISDK ASTCGKLLIF
LSVALVIMTL PFSLFVCFKV VQEYERAVIF RLGRLMQGGA KGPGIFFILP CIDSYARVDL
RTRTYDVPPQ EVLTKDSVTV SVDAVVYYRV SNATVSIANV ENAHHSTRLL AQTTLRNTMG
TRHLHEILSE RMTISGTMQV QLDEATDAWG IKVERVEIKD VRLPVQLQRA MAAEAEAARE
ARAKVIAAEG EQKASRALRE ASEVIGDSPA ALQLRYLQTL NTISAEKNST IVFPLPIDLI
TYFLKTNEAT TQQNARAAAA AIGNTPPPLQ LAPQQQMGQQ QQPQYQQPQQ QQQQYQPQQQ
QQQQQQQPQQ QDQLYQQGQQ ISSAM
