ID   SYR_NOCFA               Reviewed;         552 AA.
AC   Q5Z0Z9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=NFA_10470;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; AP006618; BAD55892.1; -; Genomic_DNA.
DR   RefSeq; WP_011207577.1; NC_006361.1.
DR   AlphaFoldDB; Q5Z0Z9; -.
DR   SMR; Q5Z0Z9; -.
DR   STRING; 247156.NFA_10470; -.
DR   EnsemblBacteria; BAD55892; BAD55892; NFA_10470.
DR   GeneID; 61131869; -.
DR   KEGG; nfa:NFA_10470; -.
DR   eggNOG; COG0018; Bacteria.
DR   HOGENOM; CLU_006406_0_1_11; -.
DR   OMA; NKPLHLG; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..552
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000242058"
FT   MOTIF           130..140
FT                   /note="'HIGH' region"
SQ   SEQUENCE   552 AA;  59065 MW;  FCE2A0FCFC6A59AA CRC64;
     MTPADLADLL RATAAKVLAE RGLDPAVLPD EVTVERPRNP EHGDYATNLA MKVAKKAGTN
     PRDLAGWLAE ALGAADGITS AEVAGPGFLN IRLAAAAQGA VLEQVLAAGS GYGTADTLRG
     TKINLEFVSA NPTGPIHLGG TRWASVGDAL GRILAAQGAD VTREYYFNDH GAQIDRFANS
     LVAAATGQPT PDDGYAGAYI GEIAEQIVAE HPEAPTLPAD QRHELFRAEG VELMFAHIKR
     TLHEFGTDFD VYFNESTLFA SGAVEQAVET LKASGDLYEK DGAWWIASSE YGDDQDRVVI
     KSDGNAAYIA GDIAYFQNKR SRGFDLCIYM LGADHHGYIG RLKAAAAAFG DDPATVEVLI
     GQMVNLVRDG QAVKMSKRAG TVVTLDDLVE AIGVDAARYA LVRWSVNSSV DIDLNLWTSQ
     KNENPVYYVQ YAHARTASIG RNAAAFDYAS VTPDLSQLTA EEEGELIRTI GEYPRVVASA
     ASLREPHRVA RYLEELAGAY HRFQTNSKLR VLPLGDDPVS PLNAARLVLV NATRQVLANG
     LALLGVSAPE QM