ID   SYR_PHEZH               Reviewed;         593 AA.
AC   B4R8T9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=PHZ_c2895;
OS   Phenylobacterium zucineum (strain HLK1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Phenylobacterium.
OX   NCBI_TaxID=450851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HLK1;
RX   PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA   Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT   "Complete genome of Phenylobacterium zucineum - a novel facultative
RT   intracellular bacterium isolated from human erythroleukemia cell line
RT   K562.";
RL   BMC Genomics 9:386-386(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; CP000747; ACG79304.1; -; Genomic_DNA.
DR   RefSeq; WP_012523442.1; NC_011144.1.
DR   AlphaFoldDB; B4R8T9; -.
DR   SMR; B4R8T9; -.
DR   STRING; 450851.PHZ_c2895; -.
DR   PRIDE; B4R8T9; -.
DR   EnsemblBacteria; ACG79304; ACG79304; PHZ_c2895.
DR   KEGG; pzu:PHZ_c2895; -.
DR   eggNOG; COG0018; Bacteria.
DR   HOGENOM; CLU_006406_5_1_5; -.
DR   OMA; NKPLHLG; -.
DR   OrthoDB; 1146366at2; -.
DR   Proteomes; UP000001868; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..593
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_1000095388"
FT   MOTIF           123..133
FT                   /note="'HIGH' region"
SQ   SEQUENCE   593 AA;  64241 MW;  27945A89A03EC77D CRC64;
     MSDLKTALGE AVEAAFAAEG VPAELARVTA SDRPDLADFQ SNGALAAAKR VGKNPREIAT
     AVAGRLQGDP RLASVEIAGP GFLNLKVADA ALAARADAIA ADPRAGAGTV PAPRRVIVDY
     GGPNVAKPMH VGHLRASIIG ESVKRLYRFR GDTVIGDAHF GDWGYQMGLL IGAVCDEDAE
     IRALVDQLNA SGDPNGEIPA AFERVTLADL DRLYPLAAAK GKEDPAYRDR ARKLTADLQA
     HKPGCYLLWR RFRDVTQVAL ERDFHALGVD FDWWKGESDV DHLIQPMVAE LADKGLLVDD
     QGARIVRVAR EGDKRELPPL LVVSSEGSAM YGTTDLATIL DRKREFDPQL VIYCVDQRQA
     DHFEIVFRAA YLAGYAEEGQ LEHIGFGTMN GTDGKPFKTR EGGVLKLADL IEMTRSKARE
     RLHEAGLGED LPAEEFEDIA GKVAVAALKF ADLSNFRGTS YVFDLDRFTS FEGKTGPYLL
     YQAVRVKSLL RKAEAEGAQA GPVTVAEPAE RDLVLTLDAF ETALQEAYDK KAPNALAEHA
     YRLSQAFSKF YAACPILAAP PPVRGSRLTL AQATLRQLEL ALDILGIAVP ERM