ID   SYR_PYRAR               Reviewed;         630 AA.
AC   A4WLP0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=Pars_1756;
OS   Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=340102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700994 / DSM 13514 / JCM 11321 / PZ6;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Cozen A.E.,
RA   Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.;
RT   "Complete sequence of Pyrobaculum arsenaticum DSM 13514.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; CP000660; ABP51307.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4WLP0; -.
DR   SMR; A4WLP0; -.
DR   STRING; 340102.Pars_1756; -.
DR   EnsemblBacteria; ABP51307; ABP51307; Pars_1756.
DR   KEGG; pas:Pars_1756; -.
DR   HOGENOM; CLU_006406_6_1_2; -.
DR   OMA; NKPLHLG; -.
DR   PhylomeDB; A4WLP0; -.
DR   Proteomes; UP000001567; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 2.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..630
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_1000018097"
FT   MOTIF           120..130
FT                   /note="'HIGH' region"
SQ   SEQUENCE   630 AA;  71544 MW;  DC8A880FD4D58C43 CRC64;
     MDPLKLPKQE FADALGKISS RLGLAEVPEI EKTRRYGYFS ARFHKYKIDP TRLRDAVEEL
     SNAGFQYISG LSAEGLYVNA DLNAKRLGEL VFEAVAKMGK KYGFTEECQL GSFLVEHTSA
     NPIHPLHIGH GRNAILGDSL ARLLRFCDNR VEVHFYVDDC GVQVMYATIG YNAVRDEARE
     WIERAKPDLV VGHIYSATNA VAEIGRLKKE AERAQDDEHK RSLIGEIDEW VAVLKRLMES
     EGDLVAKVVE RLGQRDVAGE AVELNRRYEA GDPEAKRVVR EVVDLVLRGQ RETLARLGIE
     IDRWDYESEL AVWSGEASRI VEELQRRWPQ YVEYKGGAVV FRADKFVDDF KLWDVLDLPK
     FIPPVTLTRS DGTTLYVTRD VAYALWQARQ GFDKVVRVIS TEQTHEQAHV RIILYALGFE
     DVAKKIVHYA YEMVNLPGMK MSARRGRYIS LDEILDEAAE RSASLVKEKS PEIAGVIAEK
     VGVGSVRYAF LSTSPRKPIE FRWEVVLNLR QNSGTFLQYT YVRAYSILEK APDVERASVP
     EQMLEEEKEL LVKIAEWPSV VREAVRALRP DYVAEYLDGL ALLFNSYYEK APVLKAVEGV
     RKFRIALVNA VKTVLEAGFY ILGIPTLTKM