ID   BNIP3_CAEBR             Reviewed;         220 AA.
AC   A8XPY4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=BNIP3 homolog {ECO:0000250|UniProtKB:Q09969};
DE            Short=CbBNIP3 {ECO:0000250|UniProtKB:Q09969};
DE   AltName: Full=Daf-16/FOXO controlled germline tumor affecting {ECO:0000250|UniProtKB:Q09969};
GN   Name=dct-1 {ECO:0000312|EMBL:CAP34710.2}; ORFNames=CBG16854;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP34710.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP34710.2};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Initiates apoptosis in a BH3-independent mechanism possibly
CC       by recruiting ced-3 to mitochondria and other cytoplasmic membranes.
CC       Has a role in lifespan and tumor growth (By similarity).
CC       {ECO:0000250|UniProtKB:Q09969}.
CC   -!- SUBUNIT: Homodimer; via transmembrane domain. Interacts with ced-3 and
CC       ced-9 (By similarity). {ECO:0000250|UniProtKB:Q09969}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000255}; Single-pass
CC       membrane protein {ECO:0000255}.
CC   -!- PTM: Ubiquitinated and degraded by the proteasome.
CC       {ECO:0000250|UniProtKB:Q09969}.
CC   -!- SIMILARITY: Belongs to the NIP3 family. {ECO:0000255}.
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DR   EMBL; HE601001; CAP34710.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XPY4; -.
DR   STRING; 6238.CBG16854; -.
DR   WormBase; CBG16854a; CBP42031; WBGene00036679; Cbr-dct-1.
DR   eggNOG; ENOG502SF13; Eukaryota.
DR   HOGENOM; CLU_1251645_0_0_1; -.
DR   InParanoid; A8XPY4; -.
DR   OMA; SPHVEFE; -.
DR   OrthoDB; 1250566at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0002020; F:protease binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR   GO; GO:0097345; P:mitochondrial outer membrane permeabilization; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0043067; P:regulation of programmed cell death; IBA:GO_Central.
DR   InterPro; IPR010548; BNIP3.
DR   PANTHER; PTHR15186; PTHR15186; 1.
DR   Pfam; PF06553; BNIP3; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix; Ubl conjugation.
FT   CHAIN           1..220
FT                   /note="BNIP3 homolog"
FT                   /id="PRO_0000374068"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..207
FT                   /note="Required for initiation of apoptosis"
FT                   /evidence="ECO:0000250|UniProtKB:Q09969"
FT   COMPBIAS        14..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   220 AA;  24633 MW;  E874D009DB647FA3 CRC64;
     MLDIKKKINF ANVSGEKTDE SSSSSAQQSS EQQQAAQPLA PQQTTPTAKA TNPFITPMTE
     STPGMSESWV ELAPSRTSLC SSVDINMVII DEKDKDSRLS PVSIAQSPHV EFESLEQVKY
     KLVREMLPPG KNTDWMWDWS SRPENTPPKT IRMVQYGSNL TTPPNSPEPE MSQYMPYESD
     SLFNVRVVFG FLVTNIFSFV VGAAVGFAVC RKIIKHHRHY