BNIP5_HUMAN
ID BNIP5_HUMAN Reviewed; 652 AA.
AC P0C671; B2RTY8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Protein BNIP5 {ECO:0000305};
GN Name=BNIP5 {ECO:0000312|HGNC:HGNC:33769}; Synonyms=C6orf222;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal liver;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-302, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
CC -!- INTERACTION:
CC P0C671; Q07817: BCL2L1; NbExp=3; IntAct=EBI-12806802, EBI-78035;
CC P0C671; Q92843: BCL2L2; NbExp=3; IntAct=EBI-12806802, EBI-707714;
CC P0C671; Q12982: BNIP2; NbExp=3; IntAct=EBI-12806802, EBI-752094;
CC P0C671; P45984: MAPK9; NbExp=3; IntAct=EBI-12806802, EBI-713568;
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DR EMBL; BX648558; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; Z84484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03884.1; -; Genomic_DNA.
DR EMBL; BC140873; AAI40874.1; -; mRNA.
DR CCDS; CCDS34439.1; -.
DR RefSeq; NP_001010903.3; NM_001010903.4.
DR RefSeq; XP_011512898.1; XM_011514596.2.
DR AlphaFoldDB; P0C671; -.
DR SMR; P0C671; -.
DR BioGRID; 133119; 162.
DR IntAct; P0C671; 8.
DR STRING; 9606.ENSP00000418983; -.
DR iPTMnet; P0C671; -.
DR PhosphoSitePlus; P0C671; -.
DR BioMuta; C6orf222; -.
DR DMDM; 167008722; -.
DR jPOST; P0C671; -.
DR MassIVE; P0C671; -.
DR PaxDb; P0C671; -.
DR PeptideAtlas; P0C671; -.
DR PRIDE; P0C671; -.
DR ProteomicsDB; 52323; -.
DR TopDownProteomics; P0C671; -.
DR Antibodypedia; 49825; 52 antibodies from 10 providers.
DR DNASU; 389384; -.
DR Ensembl; ENST00000437635.3; ENSP00000418983.1; ENSG00000189325.7.
DR GeneID; 389384; -.
DR KEGG; hsa:389384; -.
DR MANE-Select; ENST00000437635.3; ENSP00000418983.1; NM_001010903.5; NP_001010903.3.
DR UCSC; uc003oly.4; human.
DR CTD; 389384; -.
DR GeneCards; BNIP5; -.
DR HGNC; HGNC:33769; BNIP5.
DR HPA; ENSG00000189325; Tissue enriched (intestine).
DR neXtProt; NX_P0C671; -.
DR VEuPathDB; HostDB:ENSG00000189325; -.
DR eggNOG; ENOG502T262; Eukaryota.
DR GeneTree; ENSGT00390000001176; -.
DR HOGENOM; CLU_028338_0_0_1; -.
DR InParanoid; P0C671; -.
DR OMA; RCPRKPL; -.
DR OrthoDB; 475879at2759; -.
DR PhylomeDB; P0C671; -.
DR TreeFam; TF338223; -.
DR PathwayCommons; P0C671; -.
DR SignaLink; P0C671; -.
DR BioGRID-ORCS; 389384; 5 hits in 1040 CRISPR screens.
DR ChiTaRS; C6orf222; human.
DR GenomeRNAi; 389384; -.
DR Pharos; P0C671; Tdark.
DR PRO; PR:P0C671; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P0C671; protein.
DR Bgee; ENSG00000189325; Expressed in duodenum and 31 other tissues.
DR InterPro; IPR031362; BNIP5.
DR PANTHER; PTHR22435; PTHR22435; 1.
DR Pfam; PF15661; CF222; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Reference proteome; Ubl conjugation.
FT CHAIN 1..652
FT /note="Protein BNIP5"
FT /id="PRO_0000317187"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..164
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..452
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 302
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447"
FT VARIANT 582
FT /note="L -> V (in dbSNP:rs743852)"
FT /id="VAR_056808"
FT CONFLICT 118
FT /note="K -> R (in Ref. 1; BX648558)"
FT /evidence="ECO:0000305"
FT CONFLICT 574
FT /note="S -> P (in Ref. 1; BX648558)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 652 AA; 71930 MW; C02ED8630E79D9A6 CRC64;
MENPRCPRRP LAEKKARSLD RPQAPGKGSE SWDCHWLSLP TAPSRKALHW TTSDWARHSD
SPAPSAEAHC TTAAAPTPEE TGDFLPSEQR PSQDTKKGWL KTMLNFFVRT GPEEPREKAS
RRPRGKEGIS QHPEPLEAAG EPALRKKAHH DKKPSRKKQG HKKHAAEVTK AAQDQEARGR
EEGLSKAAAA LRSGEADLGP ARRGGEDSDH QSFLIKVDGT GALDVSPHAT GHQQEEELKK
PDQDAIIQMI VELLKRVGDQ WEEEQSLASQ LGVALPNPAP AVRKKSQEKK TSLKRTSKTN
PKKHGSEEAK RGAADVSSPE AWPPKKSSFL PLCVSGHRPS ISSSYGLEEP KVQEAPSTEA
GAPGPSVLPT PSESQEPGEE LPLDRASEYK EFIQKIISML QDAEEQQGEE QPQVQQEEVG
VENPAPHCRR KSQEKRSSFR RAFYHKKHTS KEPRRAGAAG AASPEARRPK RPSFLPLCVG
GHRPSTSSSL DPEDLECREP LPAEGEPVVI SEAPSQARGH TPEGAPQLSG ACESKEIIIQ
KLVALLQEVD GQLGQQIRRH PSFKRFFYEF SDSSLSKLVA TLRSQVAHSS KLDRNRARRL
YQFDVSLANK FAGSNSHAMC ILMGLRDHYN CTQFPYREDQ PNITSPKVES PD
