BNIPL_MOUSE
ID BNIPL_MOUSE Reviewed; 328 AA.
AC Q99JU7; Q923E3;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein;
GN Name=Bnipl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in
CC promoting cell death.
CC -!- SUBUNIT: Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER (By
CC similarity). {ECO:0000250}.
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DR EMBL; BC005659; AAH05659.1; -; mRNA.
DR EMBL; BC006585; AAH06585.1; -; mRNA.
DR AlphaFoldDB; Q99JU7; -.
DR STRING; 10090.ENSMUSP00000102813; -.
DR iPTMnet; Q99JU7; -.
DR PhosphoSitePlus; Q99JU7; -.
DR PaxDb; Q99JU7; -.
DR PRIDE; Q99JU7; -.
DR ProteomicsDB; 273791; -.
DR Antibodypedia; 20308; 102 antibodies from 23 providers.
DR Ensembl; ENSMUST00000137250; ENSMUSP00000115197; ENSMUSG00000028115.
DR MGI; MGI:2384749; Bnipl.
DR VEuPathDB; HostDB:ENSMUSG00000028115; -.
DR eggNOG; ENOG502QUPS; Eukaryota.
DR GeneTree; ENSGT00940000161723; -.
DR HOGENOM; CLU_039135_1_0_1; -.
DR InParanoid; Q99JU7; -.
DR PhylomeDB; Q99JU7; -.
DR PRO; PR:Q99JU7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q99JU7; protein.
DR Bgee; ENSMUSG00000028115; Expressed in lip and 52 other tissues.
DR ExpressionAtlas; Q99JU7; baseline and differential.
DR Genevisible; Q99JU7; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0040009; P:regulation of growth rate; ISO:MGI.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR Pfam; PF12496; BNIP2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Reference proteome.
FT CHAIN 1..328
FT /note="Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-
FT like protein"
FT /id="PRO_0000210771"
FT DOMAIN 162..323
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 36785 MW; BE1F7790F5F885F0 CRC64;
MKLGELELRE EWQDEEFPRL LPEEPGSPGD PEDPQRGSQA GTPSSLALCG QRPMRKRLSA
PEWQLSLTEG TGENGASPTR SASSSSAGSL DLEVDELETP SDSEQLDSGH EFEWEDDLPR
AEGLGASEAA ERLGRGCVCD VAGEDGHRWR VFRTGQREQR VDMTIIEPYK KVLSHGGYHG
DGLNAVILFA SCYLPRSSIP NYTYIMEHLF RYMVGTLELL VAENYLLVHL SGGTSRAQVP
PLSWIRQCYR TLDRRLRKNL RALVVVHATW YVKAFLALVR PFISSKFTRK IRFLDSLGEL
AQLISLEQVH IPEVVRQLDR DLHGSKGT
