BNL2A_EBVB9
ID BNL2A_EBVB9 Reviewed; 60 AA.
AC P0C739; Q04361; Q8AZJ2;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Protein BNLF2a;
GN ORFNames=BNLF2a;
OS Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX NCBI_TaxID=10377;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=2117, and C666-1;
RX PubMed=17911266; DOI=10.1073/pnas.0702896104;
RA Lo A.K., To K.F., Lo K.W., Lung R.W., Hui J.W., Liao G., Hayward S.D.;
RT "Modulation of LMP1 protein expression by EBV-encoded microRNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:16164-16169(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Akata, NPC-21, NPC-56, and NPC-57;
RA Lo A.K.F., Lo K.W., To K.F., Lung R.W.M., Hui J.W.Y., Hayward S.D.;
RT "Modulation of latent membrane protein 1 expression in nasopharyngeal
RT carcinoma cells by Epstein-Barr virus encoded miRNAs.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B95-8;
RX PubMed=6087149; DOI=10.1038/310207a0;
RA Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA Tuffnell P.S., Barrell B.G.;
RT "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL Nature 310:207-211(1984).
RN [4]
RP FUNCTION, AND INTERACTION WITH HOST TAP1 AND TAP2.
RX PubMed=19201886; DOI=10.4049/jimmunol.0803218;
RA Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D.,
RA Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E.;
RT "Specific targeting of the EBV lytic phase protein BNLF2a to the
RT transporter associated with antigen processing results in impairment of HLA
RT class I-restricted antigen presentation.";
RL J. Immunol. 182:2313-2324(2009).
CC -!- FUNCTION: Participates in viral evasion from HLA class I-restricted T-
CC cell immunity. Associates with host TAP1 and TAP2 and prevents TAP-
CC mediated peptide transport and subsequent loading.
CC {ECO:0000269|PubMed:19201886}.
CC -!- SUBUNIT: Interacts with host TAP1 and TAP2.
CC {ECO:0000269|PubMed:19201886}.
CC -!- INTERACTION:
CC P0C739; Q03518: TAP1; Xeno; NbExp=9; IntAct=EBI-9346744, EBI-747259;
CC P0C739; Q03519: TAP2; Xeno; NbExp=6; IntAct=EBI-9346744, EBI-780781;
CC P0C739; O15533: TAPBP; Xeno; NbExp=6; IntAct=EBI-9346744, EBI-874801;
CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the lymphocryptovirus BNLF2a family.
CC {ECO:0000305}.
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DR EMBL; V01555; CAA24812.1; -; Genomic_DNA.
DR EMBL; X01995; CAA26024.1; -; Genomic_DNA.
DR EMBL; EF103557; ABO28739.1; -; Genomic_DNA.
DR EMBL; EF103558; ABO28741.1; -; Genomic_DNA.
DR EMBL; EF110909; ABO28743.1; -; Genomic_DNA.
DR EMBL; EF110910; ABO28745.1; -; Genomic_DNA.
DR EMBL; EF110911; ABO28747.1; -; Genomic_DNA.
DR EMBL; EF110912; ABO28749.1; -; Genomic_DNA.
DR EMBL; AJ507799; CAD53471.1; -; Genomic_DNA.
DR RefSeq; YP_401721.1; NC_007605.1.
DR SMR; P0C739; -.
DR IntAct; P0C739; 252.
DR MINT; P0C739; -.
DR DNASU; 3783720; -.
DR GeneID; 3783720; -.
DR KEGG; vg:3783720; -.
DR Proteomes; UP000153037; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039588; P:suppression by virus of host antigen processing and presentation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Host endoplasmic reticulum; Host membrane; Host-virus interaction;
KW Inhibition of host adaptive immune response by virus;
KW Inhibition of host TAP by virus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Viral immunoevasion.
FT CHAIN 1..60
FT /note="Protein BNLF2a"
FT /id="PRO_0000382427"
FT TRANSMEM 41..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 14..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 60 AA; 6540 MW; 19EAE809410982EA CRC64;
MVHVLERALL EQQSSACGLP GSSTETRPSH PCPEDPDVSR LRLLLVVLCV LFGLLCLLLI
