ID   SYR_STRCO               Reviewed;         586 AA.
AC   Q9WX29;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Arginine--tRNA ligase;
DE            EC=6.1.1.19;
DE   AltName: Full=Arginyl-tRNA synthetase;
DE            Short=ArgRS;
GN   Name=argS; OrderedLocusNames=SCO3304; ORFNames=SCE68.02;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19;
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; AL939116; CAB45338.1; -; Genomic_DNA.
DR   PIR; T36252; T36252.
DR   RefSeq; NP_627514.1; NC_003888.3.
DR   RefSeq; WP_011028896.1; NZ_VNID01000025.1.
DR   AlphaFoldDB; Q9WX29; -.
DR   SMR; Q9WX29; -.
DR   STRING; 100226.SCO3304; -.
DR   GeneID; 1098738; -.
DR   KEGG; sco:SCO3304; -.
DR   PATRIC; fig|100226.15.peg.3365; -.
DR   eggNOG; COG0018; Bacteria.
DR   HOGENOM; CLU_006406_5_1_11; -.
DR   InParanoid; Q9WX29; -.
DR   OMA; HHIGDWG; -.
DR   PhylomeDB; Q9WX29; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..586
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000151616"
FT   MOTIF           127..137
FT                   /note="'HIGH' region"
SQ   SEQUENCE   586 AA;  64704 MW;  6EA6F2158A7CB91D CRC64;
     MASVTSLSDS VQQHLASALT ATRPEAAGAD PLLRRSDRAD YQANGILALA KKTKANPREL
     AAEVVARITT GDELIEDVEV SGPGFLNITV ADRAITANLA ARLADGERLG VPLKQDAGTT
     VVDYAQPNVA KEMHVGHLRS AVIGDALRSM LDFTGEKTIG RHHIGDWGTQ FGMLIQYLFE
     HPGELAPAGD IDGEQAMSNL NRVYKASRAV FDTDEEFKER ARRRVVALQS GDKETLDLWQ
     QFVDESKVYF YSVFEKLDME IRDEEIVGES AYNDGMPETA RLLEEMGVAV RSEGALVVFF
     DEIRGKDDQP VPLIVQKADG GFGYAASDLT AIRNRVQDLH ATTLLYVVDV RQSLHFRMVF
     ETARRAGWLG DEVTAHNMGY GTVLGADGKP FKTRAGETVR LEDLLDEAVQ RAAEVVREKA
     RDLTEDEIQE RAAQVGIGAV KYADLSTSPN RDYKFDLDQM VSLNGDTSVY LQYAYARIQS
     ILRKAGEVRP AAHPELALHE AERALGLHLD AFGPTVFEAA AEYAPHKLAA YLYQLASLYT
     TFYDKCPVLK AETPEQVENR LFLCDLTART LHRGMALLGI RTPERL